津村(宍戸) 直美  Naomi Tsumura


Tel: 0166-68-2725
e-mail: nshi(at)asahikawa-med.ac.jp
*e-mailの際はアドレス中の(at)を@に変えてください

研究テーマ: 生体内のレドックス反応

学歴
1992.3 北海道大学薬学部(薬品物理化学講座) 卒業

職歴
1992.4-1993.3 ㈱新薬開発研究所 分析研究室 研究員
1993.4-2007.3 旭川医科大学化学教室 教務職員
2007.4-現在 現職(旭川医科大学化学教室 助教)


論文 (Selected)
・Specific reaction of Met 35 in amyloid beta peptide with hypochlorous acid. M. Nakamura, N. Shishido, A. Nunomura, M.A. Smith, G. Perry and T. Hayashi; Free Radical Research, 44: 734-741 (2010)

・Determining the status of copper in the urine of Long-Evans Cinnamon rats and patients with Wilson's disease. N. Shishido, K. Nakayama and M. Nakamura; Asahikawa Medical College Research Bulletin,9: 11-23 (2009)

・Three histidine residues of amyloid beta peptide control the redox activity of copper and iron. M. Nakamura, N. Shishido, A. Nunomura, M.A. Smith, G. Perry, Y. Hayashi, K. Nakayama and T. Hayashi; Biochemistry, 46(44): 12737-12743 (2007)

・One- and two-electron oxidations of antioxidants by peroxidase systems. M. Nakamura, N. Shishido; in Current Topics in Biochemistry, 19-30(Chapter 2) (2006)

・Porphyrin-induced photooxidation of conjugated bilirubin. N. Shishido, K. Nakayama, and M. Nakamura; Free Radic. Res., 37 (10): 1061-1067 (2003)

・Cu-metallothioneins (Cu(I)8-MTs) in LEC rat livers 13 weeks after birth still act as antioxidants. N. Shishido, K. Nakayama, A. Takasawa, T. Ohyama and M. Nakamura; Arch. Biochem. Biophys, 387 (2): 216-222 (2001)

・Dissociation of DNA double strand by hypohalous acids. N. Shishido, S. Nakamura and M. Nakamura; Redox Report, 5 (4): 243-247 (2000)

・肝炎発症前のLECラット肝でも,銅メタロチオネイン(Cu(I)8-MTs)は抗酸化的に働く.宍戸直美,中山憲司,高澤啓,大山徹,中村正雄; 磁気共鳴と医学,11: 131-134 (2000)

・Metal-induced hydroxyl radical generation by Cu+-metallothioneins from LEC rat liver.
M. Nakamura, K. Nakayama, N. Shishido, K. Yumino and T. Ohyama; Biochem. Biophys. Res. Commun., 231: 549-552 (1997)

・Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide. T. Hayashi, N. Shishido, K. Nakayama, A. Nunomura, M.A. Smith, G. Perry and M. Nakamura; Free Radic. Biol. Med., 43 (11): 1552-1559 (2007)

・Effects of MCI-186 upon neutrophil-derived active oxygens. K. Sumitomo, N. Shishido, H. Aizawa, N. Hasebe, K. Kikuchi and M. Nakamura; Redox Report, 12 (4): 189-194 (2007)

・Inhibitory effects of bucillamine on increased blood-retinal barrier permeability in streptozotocin-induced diabetic rats. T. Hikichi, F. Mori, M. Nakamura, N. Shishido, M. Sasaki, Y. Horikawa, and A. Yoshida; Curr. Eye Res., 25(1): 1-7 (2002)

・Inhibitory effect of bucillamine on laser-induced choroidal neovascularization in rats.
T. Hikichi, F. Mori, M. Sasaki, A. Takamiya, M. Nakamura, N. Shishido, M. Takeda, Y. Horikawa, H. Matsuoka, A. Yoshida; Curr Eye Res., 24 (1): 1-5 (2002)

・Effects of CP-060S, a novel Ca2+ channel blocker, on oxidative stress in cultured cardiac myocytes. A. Hara, T. Suzuki, H. Hashizume, N. Shishido, M. Nakamura, F. Ushikubi and Y. Abiko; Europ. J. Pharmacol, 385: 81-88 (1999)


書籍
・「生命と環境」, 林要喜知・細谷夏実・矢澤洋一 編著,ほか11名の分担, 三共出版, 2011.5

学会発表 (Selected)
・アミロイドベータペプチド(Aβ)は活性酸素(ROS)生成による酸化ストレスを抑制し化学修飾される。 中村正雄,宍戸直美,阿久津弘明,布村明彦,Smith MA,Perry G,林要喜知,林隆章; 日本動物学会第82回大会,2011.9.21 旭川

・Mechanisms for Scavenging Reactive Oxygen Species in Fish and Mammalian Spermatozoa. T. Harumi, N. Shishido, M. Nakamura, Y. Hayashi, N. Shimizu, T. Ando, R. Yanagimachi; 11th International Symposium on Spermatology, 2010.6.25 沖縄

・Specific reaction of Met35 in amyloid beta peptide with hypochlorous acid. M. Nakamura, N. Shishido, A. Nunomura, M.A. Smith, G. Perry and T. Hayashi; 6th International Human Peroxidase Meeting, 2009.4.19-22 Chapel Hill (North Carolina, USA)

・アミロイドベータペプチドと次亜塩素酸およびタウリンクロラミンとの反応。宍戸直美, 阿久津弘明, 林要喜知, 林隆章, 布村明彦,スミスMA,ペリーG, 中村正雄; 第82回日本生化学会大会, 2009.10.24


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