{"id":517,"date":"2022-12-08T22:18:49","date_gmt":"2022-12-08T13:18:49","guid":{"rendered":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/psychi\/wp\/?page_id=517"},"modified":"2024-03-14T14:43:27","modified_gmt":"2024-03-14T05:43:27","slug":"%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%88","status":"publish","type":"page","link":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/psychi\/%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%88\/","title":{"rendered":"\u30d7\u30ed\u30b8\u30a7\u30af\u30c8"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

\u3000\u5375\u9ec4\u56a2\u7531\u6765\u306e\u8caa\u98df\u7d30\u80de\u3067\u3042\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306f, \u8133\u7d44\u7e54\u306e\u4e0d\u8981\u7269\u304a\u3088\u3073\u6709\u5bb3\u7269\u8cea\u306e\u8caa\u98df\u30fb\u9664\u53bb\u3084, \u8133\u5185\u306b\u304a\u3051\u308b\u81ea\u7136\u514d\u75ab\u3092\u3064\u304b\u3055\u3069\u3063\u3066\u304a\u308a, \u3044\u308f\u3070\u8133\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u308b. \u5916\u80da\u8449\u7531\u6765\u306e\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f, \u795e\u7d4c\u7d30\u80de\u306b\u6804\u990a\u4ee3\u8b1d\u7269\u3092\u4f9b\u7d66\u3057\u305f\u308a, \u7d42\u8db3\u3067\u8133\u8840\u7ba1\u3092\u88ab\u8986\u3057\u3066\u5185\u76ae\u7d30\u80de\u3068\u5171\u306b\u30b0\u30ea\u30a2\u8840\u7ba1\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057, \u8840\u6db2\u8133\u95a2\u9580\u306e\u6a5f\u80fd\u3092\u5236\u5fa1\u3057\u305f\u308a\u3057\u3066\u3044\u308b. 1980\u5e74\u4ee3McGeer\u3089\u306f, \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5, \u30ec\u30d3\u30fc\u5c0f\u4f53\u75c5, \u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u306a\u3069\u69d8\u3005\u306a\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u75c5\u5909\u90e8\u4f4d\u306b\u5171\u901a\u3057\u3066, \u30df\u30af\u30ed\u30b0\u30ea\u30a2, \u304a\u3088\u3073\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f. McGeer\u3089\u306f\u3053\u306e\u767a\u898b\u3092\u57fa\u306b, \u6d3b\u6027\u5316\u30b0\u30ea\u30a2\u304c\u95a2\u9023\u3059\u308b\u6162\u6027\u708e\u75c7\u6027\u5909\u5316\u306b\u3088\u3063\u3066\u795e\u7d4c\u7d30\u80de\u6b7b\u304c\u60f9\u8d77\u30fb\u5897\u5f37\u3055\u308c\u308b\u3068\u3059\u308bNeuroinflammation\u4eee\u8aac\u3092\u63d0\u5531\u3057\u305f. \u8fd1\u5e74\u306ePET\u7814\u7a76, \u307e\u305f\u306f\u6b7b\u5f8c\u8133\u7814\u7a76\u306b\u3088\u3063\u3066, \u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3068\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u307f\u306a\u3089\u305a, \u7d71\u5408\u5931\u8abf\u75c7, \u5927\u3046\u3064\u75c5\u3068\u3044\u3063\u305f\u5185\u56e0\u6027\u7cbe\u795e\u75be\u60a3\u306b\u304a\u3044\u3066\u3082, \u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a, Neuroinflammation\u306f\u5e45\u5e83\u3044\u7cbe\u795e\u30fb\u795e\u7d4c\u75be\u60a3\u306b\u5171\u901a\u3057\u305f\u75c5\u614b\u56e0\u5b50\u3068\u3057\u3066\u8a8d\u77e5\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f.<\/p>\n\n\n\n

\u3000\u4e00\u65b9, \u6297\u7cbe\u795e\u75c5\u85ac, \u6297\u3046\u3064\u85ac\u3068\u3082\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u5f93\u6765, \u30e2\u30ce\u30a2\u30df\u30f3\u4eee\u8aac\u304c\u4e3b\u6d41\u3067\u3042\u3063\u305f\u304c, \u81e8\u5e8a\u52b9\u679c\u3068\u306e\u77db\u76fe\u3082\u6563\u898b\u3055\u308c\u3066\u3044\u305f. \u305d\u3053\u3067\u6211\u3005\u306f, \u65b0\u898f\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u30b0\u30ea\u30a2\u306b\u7740\u76ee\u3057, \u3053\u308c\u307e\u3067\u6297\u3046\u3064\u85ac, \u6297\u7cbe\u795e\u75c5\u85ac\u3068\u3082\u6d3b\u6027\u5316\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u305f[1-3]. \u307e\u305f\u85ac\u7269\u62b5\u6297\u6027\u30fb\u96e3\u6cbb\u6027\u306e\u5185\u56e0\u6027\u7cbe\u795e\u75be\u60a3\u306b\u6709\u52b9\u6027\u3092\u793a\u3059\u96fb\u6c17\u3051\u3044\u308c\u3093\u7642\u6cd5\uff08ECT; electroconvulsive therapy\uff09\u306f, \u5b9f\u81e8\u5e8a\u306b\u304a\u3051\u308b\u300c\u6700\u5f8c\u306e\u7826\u300d, \u3044\u308f\u3070\u73fe\u5728\u306e\u751f\u7269\u5b66\u7684\u7cbe\u795e\u79d1\u6cbb\u7642\u306e\u300c\u30dd\u30b8\u30c6\u30a3\u30d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u300d\u7684\u306a\u6cbb\u7642\u6cd5\u3067\u3042\u308b\u304c, \u305d\u306e\u52b9\u679c\u767a\u73fe\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u672a\u89e3\u660e\u3067\u3042\u308b. \u5148\u5929\u7684\u306b\u30df\u30af\u30ed\u30b0\u30ea\u30a2, \u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3068\u3082\u6d3b\u6027\u5316\u3057\u3066\u304a\u308a, \u7d71\u5408\u5931\u8abf\u75c7\u69d8, \u5927\u3046\u3064\u75c5\u69d8\u306e\u7570\u5e38\u884c\u52d5\u3092\u5448\u3059\u308bGunn\u30e9\u30c3\u30c8[4]\u306bECT\u3092\u65bd\u884c\u3057, ECT\u306e\u52b9\u679c\u767a\u73fe\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u691c\u8a0e\u3057\u305f\u7d50\u679c, ECT\u306f\u7570\u5e38\u884c\u52d5\u306e\u6539\u5584\u306b\u4f34\u3044, \u6d3b\u6027\u5316\u30df\u30af\u30ed\u30b0\u30ea\u30a2, \u6d3b\u6027\u5316\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3092\u5171\u306b\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f[5]. \u307e\u305f, \u6d3b\u6027\u5316\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f\u30b0\u30ea\u30a2\u8840\u7ba1\u8907\u5408\u4f53\u306e\u5f62\u6210\u7570\u5e38\u3092\u6765\u3059\u304c, ECT\u306f\u6cbb\u7642\u52b9\u679c\u767a\u73fe\u306e\u969b, \u30b0\u30ea\u30a2\u8840\u7ba1\u8907\u5408\u4f53\u306e\u5f62\u6210\u7570\u5e38\u3092\u662f\u6b63\u3057, \u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u7d42\u8db3\u306b\u3088\u308b\u8133\u8840\u7ba1\u88ab\u8986\u7387\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f[6]. \u4eca\u5f8c\u3082\u30b0\u30ea\u30a2\u306e\u89b3\u70b9\u304b\u3089, \u3088\u308a\u8a73\u7d30\u306aECT\u52b9\u679c\u767a\u73fe\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u660e\u3057, \u5185\u56e0\u6027\u7cbe\u795e\u75be\u60a3\u306e\u7a76\u6975\u306e\u6cbb\u7642\u6a19\u7684\u5206\u5b50\u306e\u540c\u5b9a, \u3055\u3089\u306b\u306f\u65b0\u898f\u6cbb\u7642\u6cd5\u30fb\u4e88\u9632\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3059.<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n
    \n
  1. Hashioka S, Klegeris A, Monji A, Kato T, Sawada M, McGeer PL, Kanba S. Antidepressants inhibit interferon-\u03b3-induced microglial production of IL-6 and nitric oxide. Exp. Neurol. 2007. 206: 33-42. (CI=257)<\/li>\n\n\n\n
  2. Kato T, Monji A, Hashioka S, Kanba S. Risperidone significantly inhibits interferon-\u03b3-induced microglial activation in vitro. Schizophr. Res. 2007. 92: 108-115. (CI=230)<\/li>\n\n\n\n
  3. Bian Q, Kato T, Monji A, Hashioka S, Mizoguchi Y, Horikawa H, Kanba S. The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-\u03b3. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008. 32: 42-48. (CI=214)<\/li>\n\n\n\n
  4. Arauchi R* and Hashioka S* et al. <\/strong>Gunn rats with glial activation in the hippocampus show prolonged immobility time in the forced swimming test and tail suspension test. Brain Behav. 2018. e01028. *equal contribution (CI=33)<\/li>\n\n\n\n
  5. Limoa E and Hashioka S et al. Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and ameliorated schizophrenia-like behavior of Gunn rat. J. Neuroinflammation 2016. 13: 230. (CI=42)<\/li>\n\n\n\n
  6. Azis IA and Hashioka S et al. Electroconvulsive shock restores the decreased coverage of brain blood vessels by astrocytic endfeet and ameliorates depressive-like behavior. J. Affect. Dis. 2019. 257: 331-339. (CI=21)<\/li>\n<\/ol>\n\n\n\n
    <\/div>\n\n\n\n
    \n\n\n\n
    <\/div>\n\n\n\n
    \"\"<\/figure>\n\n\n\n

    \u3000\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f, \u30b0\u30ea\u30a2\u4e2d\u3067\u306f\u6700\u3082\u6570\u304c\u591a\u304f, \u795e\u7d4c\u7d30\u80de\u3068\u540c\u3058\u5916\u80da\u8449\u7531\u6765\u3067\u3042\u308b. \u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f\u8840\u6db2\u8133\u95a2\u9580\u306e\u6a5f\u80fd\u5236\u5fa1\u3084\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u8abf\u7bc0\u3068\u3044\u3063\u305f, \u8133\u306e\u6052\u5e38\u6027\u7dad\u6301\u306b\u5fc5\u9808\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b. \u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u75c5\u5909\u90e8\u4f4d\u306b\u304a\u3044\u3066, \u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u540c\u69d8, \u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5f62\u614b\u5b66\u7684\u306b\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u308b\u304c, \u6d3b\u6027\u5316\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u6a5f\u80fd\u3068\u3057\u3066\u306f, \u795e\u7d4c\u50b7\u5bb3\u7684\u306b\u50cd\u3044\u3066\u3044\u308b\u306e\u304b, \u795e\u7d4c\u4fdd\u8b77\u7684\u306b\u50cd\u3044\u3066\u3044\u308b\u306e\u304b, \u5404\u3005\u3092\u793a\u5506\u3059\u308b\u7814\u7a76\u7d50\u679c\u304c\u3053\u308c\u307e\u3067\u5831\u544a\u3055\u308c\u3066\u304a\u308a, \u672a\u3060\u8b70\u8ad6\u306e\u6c7a\u7740\u304c\u3064\u3044\u3066\u3044\u306a\u3044.<\/p>\n\n\n\n

    \u3000\u30d2\u30c8\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f, \u5185\u6bd2\u7d20\u30ea\u30dd\u30dd\u30ea\u30b5\u30c3\u30ab\u30e9\u30a4\u30c9\u3092\u542b\u3080\u69d8\u3005\u306a\u708e\u75c7\u60f9\u8d77\u56e0\u5b50\u306e\u3046\u3061, \u4e3b\u306bT\u7d30\u80de\u304c\u7523\u751f\u3059\u308b\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3Interferon (IFN)-\u03b3\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u305f\u5834\u5408\u306e\u307f, \u795e\u7d4c\u6bd2\u6027\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u3092\u6211\u3005\u306f\u660e\u3089\u304b\u306b\u3057\u305f[1]. \u5b9f\u969b, \u30d2\u30c8\u8133\u306b\u304a\u3044\u3066IFN-\u03b3\u53d7\u5bb9\u4f53\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u306e\u306f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u307f\u3067[1, 2], \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5, \u30ec\u30d3\u30fc\u5c0f\u4f53\u75c5, \u591a\u767a\u6027\u786c\u5316\u75c7\u60a3\u8005\u306e\u6b7b\u5f8c\u8133\u3067\u306f\u6d3b\u6027\u5316\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306b\u3088\u308bIFN-\u03b3\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u304c\u4ea2\u9032\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f[1]. \u6587\u732e\u7684\u306b, \u3053\u308c\u3089\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u60a3\u8005\u306e\u6b7b\u5f8c\u8133, \u3042\u308b\u3044\u306f\u8133\u810a\u9ac4\u6db2\u306b\u304a\u3044\u3066, IFN-\u03b3\u305d\u306e\u3082\u306e\u306e\u767a\u73fe\u304c\u4ea2\u9032\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u308b. \u307e\u305f, IFN-\u03b3\u6d3b\u6027\u5316\u30d2\u30c8\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u795e\u7d4c\u6bd2\u6027\u306f, \u708e\u75c7\u6027\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bSignal Transduction and Activator of Transcription (STAT)3\u306e705\u30c1\u30ed\u30b7\u30f3\u6b8b\u57fa\u306e\u30ea\u30f3\u9178\u5316\u3092\u4ecb\u3057\u3066\u767a\u73fe\u3059\u308b\u3053\u3068\u3092\u89e3\u660e\u3057\u305f[3]. \u3055\u3089\u306b, \u305d\u306e\u795e\u7d4c\u6bd2\u6027\u3092\u6709\u610f\u306b\u6291\u5236\u3059\u308b\u85ac\u5264\u3092\u30c9\u30e9\u30c3\u30b0\u30ea\u30dd\u30b8\u30b7\u30e7\u30cb\u30f3\u30b0\u306b\u3088\u3063\u3066\u8907\u6570\u7a2e\u540c\u5b9a\u3057\u305f. \u5177\u4f53\u7684\u306b\u306f, \u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264[4], L\u578b\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u5264[5], \u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264[6]\u306f\u3044\u305a\u308c\u3082\u6d3b\u6027\u5316\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u5185\u306b\u304a\u3051\u308bSTAT3\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f.<\/p>\n\n\n\n

    \u3000\u4ee5\u4e0a\u3088\u308a, \u6d3b\u6027\u5316\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306b\u3088\u308b\u795e\u7d4c\u6bd2\u6027\u306f, \u4e2d\u6838\u7684\u75c5\u614b\u6a5f\u5e8f\u3068\u306f\u8a00\u3048\u306a\u3044\u307e\u3067\u3082, \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u306f\u3058\u3081, \u8a8d\u77e5\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3055\u307e\u3056\u307e\u306a\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u304a\u3051\u308b\u5171\u901a\u3057\u305fdriving force\u3068\u3057\u3066\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b. \u4eca\u5f8c, \u3055\u3089\u306b\u8a73\u7d30\u306a\u6d3b\u6027\u5316\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306b\u3088\u308b\u795e\u7d4c\u969c\u5bb3\u6a5f\u5e8f\u3092\u89e3\u660e\u3057, \u305d\u306e\u77e5\u898b\u3092\u3082\u3068\u306b\u8a8d\u77e5\u75c7\u306e\u65b0\u898f\u6cbb\u7642\u6cd5\u958b\u767a\u3092\u76ee\u6307\u3059.<\/p>\n\n\n

    \n
    \"\"<\/figure>\n<\/div>\n\n\n
      \n
    1. Hashioka S, Klegeris A, Schwab C, McGeer PL. Interferon-\u03b3-dependent cytotoxic activation of human astrocytes and astrocytoma cells. Neurobiol. Aging 2009. 30: 1924-1935. (CI=111)<\/li>\n\n\n\n
    2. Hashioka S, Klegeris A, Schwab C, Yu S, McGeer PL. Differential expression of interferon-\u03b3 receptor on human glial cells in vivo and in vitro. J. Neuroimmunol. 2010. 225: 91-99. (CI=57)<\/li>\n\n\n\n
    3. Hashioka S, Klegeris A, Qing H, McGeer PL. STAT3 inhibitors attenuate interferon-\u03b3-induced neurotoxicity and inflammatory molecule production by human astrocytes. Neurobiol. Dis. 2011. 41: 299-307. (CI=46)<\/li>\n\n\n\n
    4. Hashioka S, Klegeris A, McGeer PL. Proton pump inhibitors reduce interferon-\u03b3-induced neurotoxicity and STAT3 phosphorylation of human astrocytes. Glia 2011. 59: 833-840. (CI=40)<\/li>\n\n\n\n
    5. Hashioka S, Klegeris A, McGeer PL. Inhibition of human astrocyte and microglia neurotoxicity by calcium channel blockers. Neuropharmacology 2012. 63: 685-691. (CI=68)<\/li>\n\n\n\n
    6. Hashioka S, Klegeris A, McGeer PL. The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-\u03b3. J. Neuroinflammation 2012. 9: 113. (CI=25)<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      \u3000\u5375\u9ec4\u56a2\u7531\u6765\u306e\u8caa\u98df\u7d30\u80de\u3067\u3042\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306f, \u8133\u7d44\u7e54\u306e\u4e0d\u8981\u7269\u304a\u3088\u3073\u6709\u5bb3\u7269\u8cea\u306e\u8caa\u98df\u30fb\u9664\u53bb\u3084, \u8133\u5185\u306b\u304a\u3051\u308b\u81ea\u7136\u514d\u75ab\u3092\u3064\u304b\u3055\u3069\u3063\u3066\u304a\u308a, \u3044\u308f\u3070\u8133\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u308b. \u5916\u80da\u8449\u7531\u6765\u306e\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f, \u795e\u7d4c\u7d30\u80de\u306b […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":26,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-517","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/psychi\/wp-json\/wp\/v2\/pages\/517","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/psychi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/psychi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/psychi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/psychi\/wp-json\/wp\/v2\/comments?post=517"}],"version-history":[{"count":19,"href":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/psychi\/wp-json\/wp\/v2\/pages\/517\/revisions"}],"predecessor-version":[{"id":1550,"href":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/psychi\/wp-json\/wp\/v2\/pages\/517\/revisions\/1550"}],"wp:attachment":[{"href":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/psychi\/wp-json\/wp\/v2\/media?parent=517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}