{"id":15,"date":"2023-05-24T11:27:49","date_gmt":"2023-05-24T02:27:49","guid":{"rendered":"http:\/\/app006.xsrv.jp\/takayuki-test\/?page_id=15"},"modified":"2026-02-04T11:40:08","modified_gmt":"2026-02-04T02:40:08","slug":"publication","status":"publish","type":"page","link":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/microbio\/publication\/","title":{"rendered":"\u696d\u7e3e"},"content":{"rendered":"\n

\u539f\u8457\u8ad6\u6587<\/h4>\n\n\n\n
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  1. Matsuda T, Omiya Y, Shimizu T, Sato H, Hishiyama M, Tang M, Kinoshita M, Hara H<\/span>, Hashioka S. Interferon-\u03b3-activated adult human astrocytes induce pyroptosis in neuroblastoma cells. Brain Mechanisms<\/em><\/strong> 2026, 152, 202542.<\/li>\n\n\n\n
  2. Sato K, Tomioka M, Akiyama M, Matsuda Y, Hara H<\/span>, Sasa H, Kurashima Y, Inoue J, Fukuda S, Kim YG. Dietary fermentable polyols fuel gut inflammation through M1 macrophage polarization and gut microbiota. iScience<\/em><\/strong> 2025, 28, 112934.<\/li>\n\n\n\n
  3. Sumida K, Doi T, Obayashi K, Chiba Y, Nagasaka S, Ogino N, Miyagawa K, Baba R, Morimoto H, Hara H<\/u>, Terabayashi T, Ishizaki T, Harada M, Endo M. Caspase-4 has a role in cell division in epithelial cells through actin depolymerization. Biochemical and Biophysical Research Communications<\/em><\/strong> 2024, 695, 149394.<\/li>\n\n\n\n
  4. Tanishita Y, Sekiya H, Inohara N, Tsuchiya K, Mitsuyama M, N\u00fa\u00f1ez G, Hara H(Corresponding author)<\/span>. Listeria<\/em> Toxin Promotes Phosphorylation of the Inflammasome Adaptor ASC through Lyn and Syk to Exacerbate Pathogen Expansion. Cell Reports<\/em><\/strong> 2022, 38, 110414.<\/li>\n\n\n\n
  5. Tsuchiya K, Hosojima S, Hara H<\/u>, Kushiyama H, Mahib M. R., Kinoshita T, Suda T. Gasdermin D mediates the maturation and release of IL-1\u03b1 downstream of inflammasomes. Cell Reports<\/em><\/strong> 2021, 34, 108887.<\/li>\n\n\n\n
  6. Fang R, Uchiyama R, Sakai S, Hara H<\/u>, Tsutsui H, Suda T, Mitsuyama M, Kawamura I, Tsuchiya K. ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism. Mucosal Immunology<\/em><\/strong> 2019, 12, 1092-1103.<\/li>\n\n\n\n
  7. Hara H(Corresponding author)<\/span>, Seregin SS, Yang D, Fukase K, Chamaillard M, Alnemri ES, Inohara N, Chen GY, N\u00fa\u00f1ez G. The NLRP6 inflammasome recognizes lipoteichoic acid and regulates Gram-positive pathogen infection. Cell<\/em><\/strong> 2018, 175, 1651-1664.
    \u672c\u8ad6\u6587\u306fF1000 Prime\u3067\u63a8\u85a6\u3055\u308c\u305f(https:\/\/f1000.com\/prime\/734357156)<\/strong><\/li>\n\n\n\n
  8. Sakamoto K, Kim YG, Hara H<\/u>, Kamada N, Caballero-Flores G, Tolosano E, Soares MP, Puente JL, Inohara N, N\u00fa\u00f1ez G. IL-22 controls heme\/Iron-dependent nutritional immunity against systemic bacterial infections. Science Immunology<\/em><\/strong> 2017, 2, eaai8371.<\/li>\n\n\n\n
  9. Conos SA, Chen KW, De Nardo D, Hara H<\/u>, Whitehead L, N\u00fa\u00f1ez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proceedings of the National Academy of Sciences of the U S A<\/em><\/strong> 2017, 114, 961-969.<\/li>\n\n\n\n
  10. Hashino M, Tachibana M, Nishida T, Hara H<\/u>, Tsuchiya K, Mitsuyama M, Watanabe K, Shimizu T, Watarai M. Inactivation of the MAPK signaling pathway by Listeria monocytogenes<\/em> infection promotes trophoblast giant cell death. Frontiers in Microbiology<\/em><\/strong> 2015, 6, 1145.<\/li>\n\n\n\n
  11. Tsuchiya K, Hara H<\/u>, Fang R, Hernandez-Cuellar E, Sakai S, Daim S, Chen X, Dewamitta SR, Qu H, Mitsuyama M, Kawamura I. The adaptor ASC exacerbates lethal Listeria monocytogenes<\/em> infection by mediating IL-18 production in an inflammasome-dependent and -independent manner. European Journal of Immunology<\/em><\/strong> 2014, 44, 3696-3707.<\/li>\n\n\n\n
  12. Fang R, Hara H<\/u>, Sakai S, Hernandez-Cuellar E, Mitsuyama M, Kawamura I, Tsuchiya K. Type I interferon signaling regulates activation of the absent in melanoma 2 inflammasome during Streptococcus pneumoniae<\/em> infection. Infection and Immunity<\/em><\/strong> 2014, 82, 2310-2317.<\/li>\n\n\n\n
  13. Yang R, Xi C, Sita DR, Sakai S, Tsuchiya K, Hara H<\/u>, Shen Y, Qu H, Fang R, Mitsuyama M, Kawamura I. The RD1 locus in the Mycobacterium tuberculosis<\/em> genome contributes to the maturation and secretion of IL-1\u03b1 from infected macrophages through the elevation of cytoplasmic calcium levels and calpain activation. Pathogens and Disease<\/em><\/strong>2014, 70, 51-60.<\/li>\n\n\n\n
  14. Hara H<\/u>, Tsuchiya K, Kawamura I, Fang R, Hernandez-Cuellar E, Shen Y, Mizuguchi J, Schweighoffer E, Tybulewicz V, Mitsuyama M. Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity. Nature Immunology<\/em><\/strong> 2013, 14, 1247-1255.<\/li>\n\n\n\n
  15. Hernandez-Cuellar E, Tsuchiya K, Hara H<\/u>, Fang R, Sakai S, Kawamura I, Akira S, Mitsuyama M. Nitric oxide inhibits the NLRP3 inflammasome. Journal of Immunology<\/em><\/strong> 2012, 189, 5113-5117.<\/li>\n\n\n\n
  16. Tanaka T, Takahashi K, Yamane M, Tomida S, Nakamura S, Oshima K, Niwa A, Nishikomori R, Kambe N, Hara H<\/u>, Mitsuyama M, Morone N, Heuser JE, Yamamoto T, Watanabe A, Sato-Otsubo A, Ogawa S, Asaka I, Heike T, Yamanaka S, Nakahata T, Saito MK. Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery. Blood<\/em><\/strong> 2012, 120, 1299-1308.<\/li>\n\n\n\n
  17. Yamamoto T, Hara H<\/u>, Tsuchiya K, Sakai S, Fang R, Matsuura M, Nomura T, Sato F, Mitsuyama M, Kawamura I. Listeria monocytogenes<\/em> strain-specific impairment of the TetR regulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability. Infection and Immunity<\/em><\/strong> 2012, 80, 2323-2332.<\/li>\n\n\n\n
  18. Sugata K, Satou Y, Yasunaga J, Hara H<\/u>, Ohshima K, Utsunomiya A, Mitsuyama M, Matsuoka M. HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines. Blood<\/em><\/strong> 2012, 119, 434-444.<\/li>\n\n\n\n
  19. Fang R, Tsuchiya K, Kawamura I, Shen Y, Hara H<\/u>, Sakai S, Yamamoto T, Fernandes-Alnemri T, Yang R, Hernandez-Cuellar E, Dewamitta SR, Xu Y, Qu H, Alnemri ES, Mitsuyama M. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae<\/em> infection. Journal of Immunology<\/em><\/strong> 2011, 187, 4890-4899.<\/li>\n\n\n\n
  20. Daim S, Kawamura I, Tsuchiya K, Hara H<\/u>, Kurenuma T, Shen Y, Dewamitta SR, Sakai S, Nomura T, Qu H, Mitsuyama M. Expression of the Mycobacterium tuberculosis<\/em> PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages. Journal of Medical Microbiology<\/em><\/strong> 2011, 60, 582-591.<\/li>\n\n\n\n
  21. Nagahama M, Itohayashi Y, Hara H<\/u>, Higashihara M, Fukatani Y, Takagishi T, Oda M, Kobayashi K, Nakagawa I, Sakurai J. Cellular vacuolation induced by Clostridium perfringens<\/em> epsilon-toxin. FEBS Journal<\/em><\/strong> 2011, 278, 3395-3407.<\/li>\n\n\n\n
  22. Tsuchiya K, Hara H<\/u>, Kawamura I, Nomura T, Yamamoto T, Daim S, Dewamitta SR, Shen Y, Fang R, Mitsuyama M. Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes<\/em>. Journal of Immunology<\/em><\/strong> 2010, 185, 1186-1195.<\/li>\n\n\n\n
  23. Shen Y, Kawamura I, Nomura T, Tsuchiya K, Hara H<\/u>, Dewamitta SR, Sakai S, Qu H, Daim S, Yamamoto T, Mitsuyama M. Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes<\/em> by murine macrophages. Infection and Immunity<\/em><\/strong> 2010, 78, 2857-2867.<\/li>\n\n\n\n
  24. Dewamitta SR, Nomura T, Kawamura I, Hara H<\/u>, Tsuchiya K, Kurenuma T, Shen Y, Daim S, Yamamoto T, Qu H, Sakai S, Xu Y, Mitsuyama M. Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes<\/em>. Infection and Immunity<\/em><\/strong> 2010, 78, 1884-1894.<\/li>\n\n\n\n
  25. Kurenuma T, Kawamura I, Hara H<\/u>, Uchiyama R, Daim S, Dewamitta SR, Sakai S, Tsuchiya K, Nomura T, Mitsuyama M. The RD1 locus in the Mycobacterium tuberculosis<\/em> genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages. Infection and Immunity<\/em><\/strong> 2009, 77, 3992-4001.<\/li>\n\n\n\n
  26. Hara H<\/u>, Tsuchiya K, Nomura T, Kawamura I, Shoma S, Mitsuyama M. Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes<\/em> on cytolysin, listeriolysin O, after evasion from phagosome into the cytoplasm. Journal of Immunology<\/em><\/strong> 2008, 180, 7859-7868.<\/li>\n\n\n\n
  27. Shoma S, Tsuchiya K, Kawamura I, Nomura T, Hara H<\/u>, Uchiyama R, Daim S, Mitsuyama M. Critical involvement of pneumolysin in production of interleukin-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae <\/em>in vitro: a novel function of pneumolysin in caspase-1 activation. Infection and Immunity<\/em><\/strong> 2008, 76, 1547-1557.<\/li>\n\n\n\n
  28. Hara H<\/u>, Kawamura I, Nomura T, Tominaga T, Tsuchiya K, Mitsuyama M. Cytolysin-dependent escape of the bacterium from the phagosome is required but not sufficient for induction of the Th1 immune response against Listeria monocytogenes<\/em> infection: distinct role of Listeriolysin O determined by cytolysin gene replacement. Infection and Immunity<\/em><\/strong> 2007, 75, 3791-3801.<\/li>\n\n\n\n
  29. Nagahama M, Hara H<\/u>, Fernandez-Miyakawa M, Itohayashi Y, Sakurai J. Oligomerization of Clostridium perfringens<\/em> epsilon-toxin is dependent upon membrane fluidity in liposomes. Biochemistry<\/em><\/strong> 2006, 45, 296-302.<\/li>\n<\/ol>\n\n\n\n

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    1. Matsuda Y, Yamauchi H, Hara H(Corresponding author)<\/span>. Activation of inflammasomes and mechanisms for intracellular recognition of Listeria monocytogenes<\/em>. Microbiology and Immunology <\/em><\/strong>2023, 67, 429-437.<\/li>\n\n\n\n
    2. He Y, Hara H<\/u>, N\u00fa\u00f1ez G. Mechanism and Regulation of NLRP3 Inflammasome Activation. Trends in Biochemical Sciences <\/em><\/strong>2016, 41, 1012-1021.<\/li>\n\n\n\n
    3. Tsuchiya K and Hara H<\/u>. The inflammasome and its regulation. Critical Reviews in Immunology <\/em><\/strong>2014, 34, 41-80.<\/li>\n<\/ol>\n\n\n\n

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      1. \u539f \u82f1\u6a39<\/u>. \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3068\u75be\u60a3\u75c5\u614b. \u300c\u81e8\u5e8a\u514d\u75ab\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1\u300d 2023, 80, 76-82.<\/li>\n\n\n\n
      2. \u539f \u82f1\u6a39<\/u>. \u5c3f\u9178\u7d50\u6676\u3068\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0.\u300c\u30ea\u30a6\u30de\u30c1\u79d1\u300d 2022, 68, 412-420.<\/li>\n\n\n\n
      3. \u539f \u82f1\u6a39<\/u>. \u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3068\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0.\u300c\u708e\u75c7\u3068\u514d\u75ab\u300d 2021, 30, 14-17.<\/li>\n\n\n\n
      4. \u539f \u82f1\u6a39<\/u>, \u571f\u5c4b\u6643\u4ecb. \u30ea\u30b9\u30c6\u30ea\u30a2\u611f\u67d3\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u5f62\u6210\u6a5f\u69cb\u3068\u305d\u306e\u5f79\u5272.\u300c\u611f\u67d3\u30fb\u708e\u75c7\u30fb\u514d\u75ab\u300d 2014, 44, 2-13.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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