{"id":10,"date":"2023-05-24T11:20:05","date_gmt":"2023-05-24T02:20:05","guid":{"rendered":"http:\/\/app006.xsrv.jp\/takayuki-test\/?page_id=10"},"modified":"2025-12-20T16:26:34","modified_gmt":"2025-12-20T07:26:34","slug":"project","status":"publish","type":"page","link":"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/microbio\/project\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"\n

\u4e3b\u306a\u7814\u7a76\u30c6\u30fc\u30de<\/strong><\/h3>\n\n\n\n

\u611f\u67d3\u75c5\u614b\u306b\u304a\u3051\u308b\u7d30\u83cc\u6bd2\u7d20\u306e\u6a5f\u80fd\u89e3\u6790\u3000Functional analysis of bacterial toxins in pathogenesis<\/strong><\/strong><\/h4>\n\n\n\n
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\u7d30\u83cc\u306f\u30b0\u30e9\u30e0\u967d\u6027\u83cc\u3068\u9670\u6027\u83cc\u306b\u5927\u5225\u3055\u308c\u307e\u3059\u3002\u30b0\u30e9\u30e0\u967d\u6027\u83cc\u306f\u591a\u69d8\u306a\u75c5\u539f\u6a5f\u69cb\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u69d8\u3005\u306a\u7a2e\u985e\u306e\u6bd2\u7d20\u3092\u7523\u751f\u3059\u308b\u3053\u3068\u3067\u75c5\u539f\u6027\u3092\u767a\u63ee\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u819c\u50b7\u5bb3\u6bd2\u7d20\u306e\u4e3b\u306a\u6a5f\u80fd\u306f\u7d30\u80de\u819c\u306b\u5b54\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3067\u3059\u304c\u3001\u305d\u308c\u3060\u3051\u3067\u306a\u304f\u69d8\u3005\u306a\u751f\u7269\u6d3b\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u8fd1\u5e74\u306e\u7814\u7a76\u304b\u3089\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u5f53\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30ea\u30b9\u30c6\u30ea\u30a2\u304c\u7523\u751f\u3059\u308b\u819c\u50b7\u5bb3\u6bd2\u7d20\u304c\u611f\u67d3\u5bbf\u4e3b\u7d30\u80de\u306e\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u7279\u7570\u7684\u306a\u708e\u75c7\u5fdc\u7b54\u3092\u4ea2\u9032\u3057\u75c5\u539f\u6027\u306b\u52a0\u62c5\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\uff08\u8ad6\u6587\u53c2\u7167\uff09\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u75c5\u539f\u6bd2\u7d20\u3068\u5bbf\u4e3b\u7d30\u80de\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u611f\u67d3\u75c5\u614b\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u304b\u3089\u89e3\u660e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

Bacteria are broadly classified into Gram-positive and Gram-negative groups. Gram-positive bacteria employ a wide range of virulence mechanisms and often cause disease by producing diverse toxins. For example, pore-forming toxins primarily create pores on host cell membranes, but recent studies have shown that they also have other biological activities. Our research group has reported that a pore-forming toxin produced by Listeria<\/em> contributes to its pathogenesis by activating host kinases and thereby enhancing a specific inflammatory response (see our publication). We aim to elucidate how interactions between bacterial toxins and host cells shape infection outcomes at the molecular level.<\/p>\n\n\n\n

\u4ee3\u8868\u7684\u306a\u8ad6\u6587\uff1aTanishita Y, Sekiya H, Inohara N, Tsuchiya K, Mitsuyama M, N\u00fa\u00f1ez G, \u203bHara H<\/u>. Listeria<\/em> toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion. Cell Reports<\/em><\/strong> 2022, 38, 110414. \u203bCorresponding author<\/em><\/p>\n<\/div>\n\n\n\n

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\u611f\u67d3\u75c7\u306e\u91cd\u75c7\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u591a\u89d2\u7684\u89e3\u6790<\/strong>\u3000Multifaceted analysis of exacerbation mechanisms in infectious diseases<\/strong><\/h4>\n\n\n\n
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\u75c5\u539f\u4f53\u304c\u611f\u67d3\u3059\u308b\u3068\u514d\u75ab\u7d30\u80de\u306f\u7570\u7269\u3068\u3057\u3066\u8a8d\u8b58\u3057\u708e\u75c7\u5fdc\u7b54\u3092\u8a98\u767a\u3057\u307e\u3059\u3002\u75c5\u539f\u4f53\u3092\u611f\u77e5\u3059\u308b\u53d7\u5bb9\u4f53\u306f\u7d30\u80de\u8868\u9762\u3084\u7d30\u80de\u5185\u306b\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u7d30\u80de\u5185\u53d7\u5bb9\u4f53\u3092\u6d3b\u6027\u5316\u3059\u308b\u306e\u306f\u57fa\u672c\u7684\u306b\u75c5\u539f\u83cc\u306b\u9650\u3089\u308c\u307e\u3059\u3002\u5f53\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30ea\u30b9\u30c6\u30ea\u30a2\u3084\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306a\u3069\u304c\u7d30\u80de\u5185\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3068\u3088\u3070\u308c\u308b\u708e\u75c7\u5fdc\u7b54\u3092\u60f9\u8d77\u3057\u3001\u611f\u67d3\u75c5\u614b\u3092\u91cd\u75c7\u5316\u3055\u305b\u3066\u3044\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\uff08\u8ad6\u6587\u53c2\u7167\uff09\u3002\u3069\u306e\u3088\u3046\u306a\u5fae\u751f\u7269\u56e0\u5b50\u304c\u3053\u306e\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u5fdc\u7b54\u306e\u6d3b\u6027\u5316\u304a\u3088\u3073\u5236\u5fa1\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u304b\u3001\u307e\u305f\u3001\u3069\u306e\u3088\u3046\u306a\u6a5f\u69cb\u3067\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u4ecb\u3057\u305f\u708e\u75c7\u5fdc\u7b54\u304c\u5bbf\u4e3b\u3092\u6b7b\u306b\u81f3\u3089\u3057\u3081\u308b\u306e\u304b\u89e3\u660e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

When a pathogen infects the host, immune cells recognize it as foreign and trigger inflammatory responses. Receptors that detect pathogens are expressed on the cell surface as well as inside cells, but intracellular receptors are generally activated during pathogen infection. Our research group has reported that pathogens such as Listeria monocytogenes<\/em> and Staphylococcus aureus<\/em> induce an inflammasome-mediated inflammatory responses via intracellular receptors, thereby exacerbating infection outcomes (see our publication). We are investigating which microbial factors are involved in activating and regulating inflammasome responses, and how inflammasome-driven inflammation exacerbates infection pathogenesis.<\/p>\n\n\n\n

\u4ee3\u8868\u7684\u306a\u8ad6\u6587\uff1a\u203bHara H<\/u>, Seregin SS, Yang D, Fukase K, Chamaillard M, Alnemri ES, Inohara N, Chen GY, N\u00fa\u00f1ez G. The NLRP6 inflammasome recognizes lipoteichoic acid and regulates Gram-positive pathogen infection. Cell<\/em><\/strong> 2018, 175, 1651-1664. \u203bCorresponding author<\/em><\/p>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n

\u85ac\u5264\u8010\u6027\u83cc\u554f\u984c\u306b\u5bfe\u3059\u308b\u6311\u6226\u7684\u7814\u7a76\u3000Innovative research against antimicrobial resistance<\/h4>\n\n\n\n
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Antimicrobial resistance is one of the most serious global issues in the world. As the \u201csilent pandemic\u201d of antimicrobial resistance has become a major international concern, there is an urgent need to shift toward innovative treatment strategies beyond conventional antibiotics. With the goal of avoiding the emergence of new resistance, our group is exploring therapeutic approaches that do not directly target the pathogen itself. One promising direction is to suppress inflammatory responses that drive disease worsening, and we have recently shown that this strategy can improve outcomes in several antimicrobial-resistant infections (see our publication). We aim to identify innovative therapeutic targets and develop new treatment modalities.<\/p>\n\n\n\n

\u8ad6\u6587\uff1a\u6295\u7a3f\u6e96\u5099\u4e2d<\/p>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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