教室の業績・論文

1

布村明彦. 認知症の予防・治療. Key Words. 酸化ストレスと科学的アンチエイジング. Current Therapy 24(3):308, 2006.

2

布村明彦. かかりつけ医のための認知症Q&A. 認知症予防のために生活習慣の面から留意すべきことは何ですか. クリニシアン 53(4):51-56, 2006

3

布村明彦.　認知症予防総論. Modern Physician 26(12):1847-1851, 2006

4

稲葉央子, 石丸雄二, 田村義之, 千葉茂. 【高齢者せん妄の診断と治療】高齢者せん妄における環境調整と事故防止. 老年精神医学雑誌 17巻6号:644-652, 2006.

5

稲葉央子. 睡眠からみた心と社会 ストレスと睡眠．心と社会 37巻3号:23-28, 2006.

6

田村義之. 睡眠からみた心と社会 睡眠障害の治療の実際．心と社会 37巻3号:29-32, 2006.

7

石本隆広, 千葉茂, 尾森伸行, 山口一豪, 阪本一剛, 高崎英気, 田端一基, 石丸雄二, 田村義之, 稲葉央子．てんかん発作の発現における脳幹の役割　ラット中脳網様体への興奮性アミノ酸注入による研究．てんかんをめぐってXXV:5-17, 2006.

8

山口一豪, 田村義之, 千葉茂, 高崎英気, 田端一基, 石丸雄二, 石本隆広. アクティグラフが治療上有用であった睡眠不足症候群の1例. 臨床脳波 48巻6号:386-390, 2006.

9

小曽根基裕, 八木朝子, 伊藤洋, 田村義之, 井上雄一, 内村直尚, 佐々木三男, TerzanoMario Giovanni, 清水徹男. 睡眠パラメータCAPを用いたゾルピデムの精神生理性不眠症患者における睡眠の質(安定性)に対する検討　プラセボを対照とした無作為化クロスオーバー比較試験での検討. 新薬と臨床 55巻5号:737-753, 2006.

12

Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA. Involvement of oxidative stress in Alzheimer disease. Journal of Neuropathology and Experimental Neurology 65(7):631-641, 2006.

13

Nunomura A, Castellani RJ, Lee HG, Moreira PI, Zhu X, Perry G, Smith MA. Neuropathology in Alzheimer’s disease: awaking from a hundred-year-old dream. Science of Aging Knowledge Environment 2006(8) pe10, 2006.

14

Nunomura A, Honda K, Takeda A, Hirai K, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in neurodegenerative diseases. Journal of Biomedicine and Biotechnology 2006: article ID 82323, 6 pages, 2006.

15

Nunomura A, Zhu X, Moreira PI, Smith MA, Perry G. Involvement of oxidative stress in the early-stage of Alzheimer’s disease: implications for therapeutics. In: Trends in Alzheimer’s Disease Research, Welsh EM (Ed) Nova Science Publishers, Hauppauge, 2006, pp 161-183.

16

Tamura Y, Chiba S, Takasaki H, Tabata K, Ishimaru Y, Ishimoto T. Biperiden-induced delirium model in rats: A behavioral and electroencephalographic study. Brain Res. 1115(1):194-199, 2006.

17

Moreira PI, Honda K, Zhu X, Nunomura A, Casadesus G, Smith MA, Perry G. Brain and brawn. Parallels in oxidative strength. Neurology 66 (2 Suppl 1): S97-101, 2006.

18

Castellani RJ, Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathologica 111(6):503-509, 2006.

19

Lee HG, Perry G, Zhu X, Nunomura A, Smith MA.　Amyloid-β, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression". Free Radical Biology and Medicine 41(2):188-189, 2006.

20

Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid-β vaccination: testing the amyloid hypothesis?: heads we win, tails you lose! American Journal of Pathology 169(3):738-739, 2006.

21

Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid β: the alternate hypothesis. Current Alzheimer Research 3(1):75-80, 2006.

22

Moreira PI, Zhu X, Lee HG, Nunomura A, Smith MA, Perry G. Therapeutic potential of oxidative stress reduction in Alzheimer’s disease. Future Neurology 1(1):1-4, 2006.

23

Moreira PI, Zhu X, Nunomura A, Smith MA, Perry G. Therapeutic options in Alzheimer’s disease. Expert Review of Neurotherapeutics 6(6):897-910, 2006.

24

Lee HG, Zhu X, Drew KL, Joseph JA, Nunomura A, Hirai K, Takeda A, Perry G, Smith MA. Oxidative adaptation in aging and Alzheimer’s disease: the roles of amyloid and tau. In: Molecular Interventions in Lifestyle-related Diseases, Hiramatsu M, Yoshikawa T, Packer L (Eds) Taylor & Francis Group, Boca Raton, FL, 2006, pp 117-125.

25

Castellani RJ, Lee HG, Smith MA, Perry G, Nunomura A. Amyloid-β and tau in Alzheimer’s disease: what is the neuropathology trying to tell us? In: Oxidative Stress and Age-Related Neurodegeneration, Luo Y, Packer L (Eds) CRC Press, Boca Raton, 2006, pp 121-130.

26

Moreira PI, Zhu X, Smith MA, Perry G, Nunomura A. Antioxidant therapies in the prevention and treatment of Alzheimer disease. In: Oxidative Stress and Age-Related Neurodegeneration, Luo Y, Packer L (Eds) CRC Press, Boca Raton, 2006, pp 131-146.

1

千葉茂, 高橋道宏．The UKU side effect rating scale(UKU副作用評価尺度)日本語版およびその作成経緯．臨床精神薬理 8巻12号 1939-1961, 2005

2

千葉茂, 田村義之．せん妄をめぐって．精神神経学雑誌 107巻4号 383-388, 2005

5

布村明彦. 老年期痴呆. 薬局56（増刊号：病気と薬の説明ガイド2005） : 111-121, 2005

6

布村明彦. 酸化ストレス抑制を介したアルツハイマー病治療アプローチの現状と可能性. 老年精神医学雑誌 16(増刊号 III): 126-134, 2005

7

田村義之, 千葉茂．標準治療と最新治療　メリット・デメリット　ナルコレプシー．Clinical Neuroscience 23巻10号 1202-1203, 2005

8

田村義之, 千葉茂．【睡眠障害　最新の臨床トピックス】　睡眠障害の臨床におけるアクティグラフの有用性．Modern Physician 25巻1号 23-28, 2005

9

Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, Perry G.　Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.　Journal of Biological Chemistry 280(22):　20978-20986, 2005 (IF=6.355)

10

Liu Q, Smith MA, Avila J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, Ghanbari HA, Siedlak SL, Harris PLR, Sayre LM, Perry G. Alzheimer-specific epitopes of tau represent lipid peroxidation induced conformations. Free Radical Biology and Medicine 38(6):746-754, 2005 (IF=5.625)

11

Petersen RB, Siedlak SL, Lee HG, Kim YS, Nunomura A, Tagliavini F, Ghetti B, Cras P, Moreira PI, Castellani RJ, Guentchev M, Budka H, Ironside JW, Gambetti P, Smith MA, Perry G. Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathologica 110(3): 232-238, 2005 (IF=2.503)

12

Nunomura A, Tabata K, Chiba S, Moreira PI, Zhu X, Smith MA, Perry G. Temporal primacy of oxidative stress in the pathological cascade of Alzheimer disease. In: Oxidative Stress and Age-Related Neurodegeneration, Luo Y, Packer L (Eds) CRC Press, Boca Raton, 2005, pp 365-372

13

Liu Q, Lee HG, Honda K, Siedlak SL, Harris PLR, Cash AD, Zhu X, Avila J, Nunomura A, Takeda A, Smith MA, Perry G. Tau modifiers as therapeutic targets for Alzheimer disease. Biochimica et Biophysica Acta-Molecular Basis of Disease 1739(2-3): 211-215, 2005 (IF=3.046)

14

Smith MA, Nunomura A, Lee HG, Zhu X, Moreira PI, Avila J, Perry G. Chronological primacy of oxidative stress in Alzheimer disease. Neurobiology of Aging 26(5):579-580, 2005 (IF=5.516)

15

Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, Takeda A, Nunomura A, Smith MA. Tau phosphorylation in Alzheimer’s disease: pathogen or protector? Trends in Molecular Medicine 11(4): 164-169, 2005 (IF=7.497)

16

Moreira PI, Smith MA, Zhu X, Nunomura A, Castellani RJ, Perry G. Oxidative stress and neurodegeneration. Annals of the New York Academy of Sciences 1043:545-552, 2005 (IF=1.789)

17

Moreira PI, Oliveira CR, Santos MS, Nunomura A, Honda K, Zhu X, Smith MA, Perry G. A second look into oxidant mechanisms in Alzheimer’s disease. Current Neurovascular Research 2(2): 179-184, 2005

18

Moreira PI, Honda K, Liu Q, Santos MS, Oliveira CR, Aliev G, Nunomura A, Zhu X, Smith MA, Perry G. Oxidative stress: old enemy in Alzheimer’s disease prthophysiology. Current Alzheimer Research 2(4): 403-408, 2005

19

Moreira PI, Nunomura A, Petot GJ, Aliev G, Smith MA, Perry G. Brain metabolic alterations are early signs in Alzheimer disease pathophysiology. In: Nutrition, Cognitive Decline and Aging, Vellas B (Ed) Serdi Publisher, Paris, 2005, pp 61-65

20

Lee HG, Zhu X, Drew KL, Joseph JA, Nunomura A, Hirai K, Takeda A, Perry G, Smith MA. Oxidative adaptation in aging and Alzheimer disease: the role of amyloid and tau. In: Molecular Interventions in Lifestyle-related Diseases, Hiramatsu M, Yoshikawa T, Packer L (Eds) Dekker/CRC Press, New York, 2005

21

Castellani RJ, Lee HG, Smith MA, Perry G, Nunomura A. Amyloid-β and tau in Alzheimer’s disease: what is the neuropathology trying to tell us? In: Oxidative Stress and Age-Related Neurodegeneration, Luo Y, Packer L (Eds) CRC Press, Boca Raton, 2005, pp 121-130

22

Moreira PI, Zhu X, Smith MA, Perry G, Nunomura A. Antioxidant therapies in the prevention and treatment of Alzheimer disease. In: Oxidative Stress and Age-Related Neurodegeneration, Luo Y, Packer L (Eds) CRC Press, Boca Raton, 2005, pp 131-146

23

Chiba S, Ishimoto T, Ishimaru Y, Tamura Y, Nunomura A. Nature and consequences of seizures originating in the brainstem. In: Kindling 6, Corcoran ME and Moshe SL (Eds) Springer, New York, 2005, pp 99-113

24

Perry G, Friedland RP, Petot GJ, Nunomura A, Castellani RJ, Kubat Z, Smith MA. Alzheimer as a disease of metabolic demand: benefits of physical and brain exercise. In: Exercise and Diseases: Prevention Through Training, Radak Z (Ed) Oxford: Meyer & Meyer Sport (UK) Ltd, United Kingdom, 2005, pp 7-16

25

Moreira PI, Zhu X, Nunomura A, Honda K, Lee HG, Aliev G, Smith MA, Perry G. Oxidative stress in Alzheimer disease: an overview. In: Perspectives in Neurosciences, Baloyannis SJ (Ed) Greece Society for Amelioration of the Quality of Life for Chronic Neurologic Patients, Thessalonikh, Greece, 2005, pp 419-433

1

千葉茂．これからのメンタルヘルス　睡眠の重要性．旭川医科大学研究フォーラム 5巻1号 26-36, 2004

2

千葉茂, 石本隆広, 石丸雄二, 田端一基, 高崎英気, 田村義之．【側頭葉てんかんの発達段階による特徴】　初老期・老年期の側頭葉てんかんの発作症状．臨床脳波 46巻11号 703-708, 2004

3

千葉茂, 田村義之．【老年期精神障害の臨床像の変化と長期予後】　老年期せん妄の臨床像の特徴と予後．老年精神医学雑誌 15巻9号 1033-1039, 2004

4

千葉茂, 田村義之．【睡眠障害-最新の診断と治療】　一般臨床における鑑別診断　睡眠時随伴症の鑑別診断．カレントテラピー 22巻7号 678-683, 2004

5

千葉茂．プライマリケアにおけるこれからのメンタルヘルス　睡眠障害の診断・治療の重要性．日本医事新報 4180号 5-13, 2004

6

千葉茂, 田村義之．【生活習慣病と睡眠障害】　睡眠の問題が引き起こすもの　睡眠不足と勤務形態．Progress in Medicine 24巻4号 957-961, 2004

7

千葉茂．サーカディアンリズム睡眠障害．精神神経学雑誌 106巻3号 374-387, 2004

8

布村明彦. アルツハイマー病―早期診断と治療研究の最前線―Key Words. アミロイド. Current Therapy 22(4): 406, 2004

9

布村明彦. ビタミンEとその他の抗酸化物質による痴呆の予防と治療の可能性. Cognition and Dementia 3(2): 144-151, 2004

10

布村明彦. アルツハイマー病における酸化ストレスと神経細胞死. Dementia Japan 18(1): 12-18, 2004

11

田村義之, 白濱靖幸, 千葉茂．神経症状が遷延したセロトニン症候群の1例．精神科 5巻5号 401-405, 2004

12

石本隆広, 千葉茂, 佐藤俊樹, 黒田重利, 深津亮．困難な症例から学ぶ　初期に性別違和感が前景に立った統合失調症の一例．Schizophrenia Frontier 5巻3号 193-198, 2004

13

Nunomura A, Chiba S, Lippa CF, Cras P, Kalaria RN, Takeda A, Honda K, Smith MA, Perry G. Neuronal RNA oxidation is a prominent feature of familial Alzheimer’s disease. Neurobiology of Disease 17(1):108-113, 2004 (IF=4.389)

14

Nunomura A, Chiba S, Takeda A, Smith MA, Perry G. Oxidative stress in Alzheimer disease: the earliest cytological and biochemical feature. In: Molecular Neurobiology of Alzheimer Disease and Related Disorders, Takeda M, Tanaka T, Cacabelos R (Eds) Karger, Basel, 2004, pp 164-171

15

Castellani RJ, Honda K, Zhu X, Cash AD, Nunomura A, Perry G, Smith MA. Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease. Ageing Ressearch Review 3(3):319-326, 2004 (IF=4.953)

16

Liu Q, Xie F, Siedlak SL, Nunomura A, Honda K, Moreira PI, Zhua X, Smith MA, Perry G. Neurofilament proteins in neurodegenerative diseases. Cellular and Molecular Life Sciences 61(24):3057-3075, 2004 (IF=4.812)

17

Moreira PI, Nunomura A, Honda K, Liu Q, Aliev G, Oliveira CR, Santos MS, Zhu X, Smith MA, Perry G. Stress and homeostatic regulation of oxidative damage in neurodegenerative disease. In: International Proceedings, XII Biennial Meetings of the Society for Free Radical Research International, Puntarulo S, Boveris A (Eds) Medimond, Bologna, 2004, pp 219-224

18

Ishimoto T, Chiba S, Omori N. Convulsive seizures induced by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid microinjection into the　mesencephalic reticular formation in rats.　Brain Res. 17;1021(1):69-75. 2004

1

千葉　茂、本間研一編著：サーカディアンリズム睡眠障害の臨床, 新興医学出版社, 東京, 2003

2

千葉　茂：偽発作. 別冊日本臨床　領域別症候群シリーズ37 神経症候群�Y―てんかん症候群―, p385―389, 日本臨床社, 2003

3

千葉　茂：失神. 別冊日本臨床　領域別症候群シリーズ37 神経症候群�Y―てんかん症候群―, p390―393, 日本臨床社, 2003

4

布村明彦、千葉　茂、Smith MA、Perry G.　アルツハイマー病脳における酸化的傷害とアミロイドβ沈着. 老年期痴呆研究会誌 13: 43-45, 2003

5

布村明彦、千葉　茂、Smith MA、Perry G.アルツハイマー病と酸化的ストレス. 老年期痴呆研究会誌 13: 83-85, 2003

6

田村義之、千葉　茂：中枢神経刺激剤依存性睡眠障害. 別冊日本臨床　領域別症候群シリーズ39 精神医学症候群�U, p119―121, 日本臨床社, 2003

7

田村義之、千葉　茂：毒物起因性睡眠障害. 別冊日本臨床　領域別症候群シリーズ39 精神医学症候群�U, p122―124, 日本臨床社, 2003

8

田村義之、高田利弘、高崎英気、田端一基、石丸雄二、石本隆広、布村明彦、猪俣光孝、直江寿一郎、千葉　茂：ドネペジル投与により長期間ADAS-Jcog上の改善が維持されたアルツハイマー病の一例における経時的脳波変化. 日本薬物脳波学会雑誌 5: 14−17, 2003

9

鈴木邦夫、田村義之、千葉　茂、鈴木太郎、猪俣光孝、直江寿一郎、高崎英気、田端一基、石丸雄二、石本隆広、尾森伸行：定型抗精神病薬によってせん妄が誘発された精神分裂病の１例. 日本薬物脳波学会雑誌、5（１）：42-44、2003

10

三田村保、田村義之、千葉　茂、石丸雄二、武藤福保：血液透析による脳波変化の定量解析．臨床神経生理学、31 (1): 20―27、2003

11

Perry G, Nunomura A, Raina AK, Aliev G, Siedlak SL, Harris PL, Casadesus G, Petersen RB, Bligh-Glover W, Balraj E, Petot GJ, Smith MA. A metabolic basis for Alzheimer disease. Neurochemical Ressearch 28(10):1549-1552, 2003

12

Perry G, Srinivas R, Nunomura A, Smith MA. The role of oxidative mechanisms in neurodegenerative diseases. In: Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, Dickson DW (Ed) ISN Neuropath Press, Basel, 2003, pp 8-10

13

Cash AD, Aliev G, Siedlak SL, Nunomura A, Fujioka H, Zhu X, Vinters HV, Tabaton M, Johnson AB, Paula-Barbosa M, Avila J, Jones PK, Castellani RL, Smith MA, Perry G. Microtubule reduction in Alzheimer disease and aging is independent of tau filament formation. American Journal of Pathology 162(5): 1623-1627, 2003

14

Perry G, Taddeo MA, Petersen RB, Castellani RJ, Harris PLR, Siedlak SL, Cash AD, Liu Q, Nunomura A, Atwood CS, Smith MA. Adventiously-bound redox active iron and copper are et the center of oxidative damage in Alzheimer disease. BioMetals 16(1): 77-81, 2003

15

Chao M, Zhu X, Raina AK, Aliev G, Takeda A, Nunomura A, Tabaton M, Perry G, Smith MA. Sources contributing to the initiation and propagation of oxidative stress in Alzheimer disease. Proceedings of Indian National Science Academy B69 (2): 251-260, 2003

16

Tateyama M, Takeda A, Onodera Y, Matsuzaki M, Hasegawa T, Nunomura A, Hirai K, Perry G, Smith MA, Itoyama Y. Oxidative stress and predominant Aβ42(43) deposition in myopathies with rimmed vacuoles. Acta Neuropathologica 105(6): 581-585, 2003

17

Zhu X, Raina AK, Lee HG, Chao M, Nunomura A, Tabaton M, Petersen RB, Perry G, Smith MA.　Oxidative Stress and Neuronal Adaptation in Alzheimer Disease: The Role of SAPK Pathways. Antioxidants and Redox Signaling 5(5):571-576, 2003

18

Osaka H, Wang YL, Takada K, Takizawa S, Setsuie R, Li H, Sato Y, Nishikawa K, Sun YJ, Sakurai M, Harada T, Hara Y, Kimura I, Chiba S, Namikawa K, Kiyama H, Noda M, Aoki S, Wada K. Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet. 2003 Aug 15;12(16):1945-58

19

Cash AD, Srinivas R, Rottkamp CA, Zhu X, Taddeo MA, Aliev G, Fujioka H, Atwood CS, Sayre LM, Castellani RJ, Smith MA, Perry G, Nunomura A. Metal homeostasis and its relation to oxidative stress in Alzheimer’s disease. In: Redox-Genome Interactions in Health and Disease, Fuchs J, Podda M, Packer L (Eds) Marcel Dekker, New York, 2003, pp 425-437

20

Perry G, Raina AK, Nunomura A, Lee HG, Zhu X, Ogawa O, Liu Q, Perez M, Cash AD, Avila J, Castellani RJ, Atwood CS, Aliev G, Takeda A, Smith MA. Oxidative stress and the pathogenic mechanisms of Alzheimer disease. In: Alzheimer’s Disease and Related Disorders: Research Advances, Iqbal K, Winblad B (Eds) Ana Aslan International Academy of Aging, Bucharest, 2003, pp 425-432

1

千葉　茂、田村義之：第11章　精神・心療内科　不眠. 今月の治療第９巻　臨時増刊号　専門医がすすめる最新処方128―こんな時この処方―, p 300―301, 総合医学社, 東京, 2002

2

田村義之、田端一基、石丸雄二、石本隆広、尾森伸行、遠藤拓郎、千葉　茂、本間研一：ビペリデン投与によって誘発されるラットの行動変化―ポリグラムを用いた検討― . 日本薬物脳波学会雑誌、4（１）：27-29、2002

3

田村義之、田端一基、石本隆広、布村明彦、猪俣光孝、直江寿一郎、千葉　茂：塩酸ドネぺジルの臨床経験―臨床症状および脳波所見の変化について―. 日本薬物脳波学会雑誌、4（１）：5-7、2002

4

石本隆広、高崎英気、田端一基、石丸雄二、尾森伸行、田村義之、太田秀造、千葉　茂：Bicuculline Methiodideのラット赤核注入によって誘発された脳波および行動変化について.日本薬物脳波学会雑誌４（１）：20-22、2002

5

石本隆広、千葉　茂、高崎英気、田端一基、石丸雄二、尾森伸行、田村義之：psychogenic pseudoseizuresを呈したmitchondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) の１例. てんかんをめぐってXX�U：23-28、2002

6

高田　泉、石本隆広、田端一基、石丸雄二、尾森伸行、田村義之、千葉　茂：Carbamazepineによって、てんかん発作と精神症状が改善した前頭葉てんかんの１例. てんかんをめぐってXX�U：29-33、2002

7

Wataya T*, Nunomura A*, Smith MA, Siedlak SL, Harris PLR, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. Journal of Biological Chemistry 277(7):4644-4648, 2002 (*contributed equally to this work)

8

Castellani RL, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies. Neuroscience Letters 319(1):25-28, 2002

9

Kikuchi A, Takeda A, Onodera H, Kimpara T, Hisanaga K, Sato N, Nunomura A, Perry G, Smith MA, Itoyama Y. Systemic increase of oxidative nucleic acid damage in Parkinson’s disease and multiple system atrophy. Neurobiology of Disease 9(2):244-248, 2002

10

Aliev G, Smith MA, Seyidov D, Neal ML, Lamb BT, Nunomura A, Gasimov EK, Vinters HV, Perr G, LaManna JC, Friedland RP. The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer’s disease. Brain Pathology 12(1):21-35, 2002

11

Smith MA, Drew KL, Nunomura A, Takeda A, Hirai K, Zhu X, Atwood CS, Raina AK, Rottkamp CA, Sayre LM, Friedland RP, Perry G. Amyloid-β, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? Neurochemistry International 40(6):527-531, 2002

12

Raina AK, Sayre LM, Atwood CS, Rottkamp CA, Hochman A, Zhu X, Obrenovich ME, Shimohama S, Nunomura A, Takeda A, Perry G, Smith MA. Apoptotic and oxidative indicators in Alzheimer’s disease. In: Apoptosis techniques and protocols, 2nd Ed, LeBlanc AC (Ed) Humana Press, Totowa, NJ, 2002, pp 225-246

13

Rottkamp CA, Atwood CS, Joseph JA, Nunomura A, Perry G, Smith MA. The state versus amyloid-β: the trial of the most wanted criminal in Alzheimer disease. Peptides 23(7):1333-1341, 2002

14

Castellani RJ, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, Cash AD, Obrenovich ME, Perry G, Smith MA. The role of mitochondrial dysfunction in Alzheimer disease. Journal of Neuroscience Research 70(3): 357-360, 2002

15

Nunomura A, Chiba S, Kosaka K, Takeda A, Castellani RJ, Smith MA, Perry G. Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies. NeuroReport 13(16): 2035-2039, 2002 (Erratum: NeuroReport 14(2): 293, 2003)

16

Perry G, Taddeo MA, Nunomura A, Zhu X, Zenteno-Savin T, Drew KL, Shimohama S, Avila J, Castellani RJ, Smith MA. Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Comparative Biochemistry and Physiology C 133(4): 507-513, 2002

17

Perry G, Nunomura A, Hirai K, Zhu X, Prez M, Avila J, Castellani RJ, Atwood CS, Aliev G, Sayre LM, Takeda A, Smith MA. Is oxidative damagre the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases? Free Radical Biology and Medicine 33(11): 1475-1479, 2002

18

Perry G, Nunomura A, Cash AD, Taddeo MA, Hirai K, Aliev G, Avila J, Wataya T, Shimohama S, Atwood CS, Smith MA. Reactive oxygen: its sources and significance in Alzheimer disease. Journal of Neural Transmission Suppl (62): 69-75, 2002

19

Raina AK, Rottkamp CA, Zhu X, Ogawa O, Hochman A, Shimohama S, Takeda A, Nunomura A, Perry G, Smith MA. Neuronal survival and death in Alzheimer disease. In: Mapping the Progress of Alzheimer’s and Parkinson’s Disease, Mizuno Y, Fisher A, Hanin I (Eds) Kluwer Academic/Plenum Publishers, Dordrecht, 2002, pp 49-57

1

武田　篤、菊池昭夫、布村明彦.　酸化的ストレスと神経変性.　医学のあゆみ 198(5):349-352, 2001

2

Perry G, Nunomura A, Avila J, Perez M, Rottkamp CA, Atwood CS, Zhu X, Aliev G, Cash AD, Smith MA. Oxidative damage and antioxidant responses in Alzheimer disease. In: Alzheimer’s Disease: Advances in Etiology, Pathogenesis and Therapeutics, Iqbal K, Sisodia S, Winblad B (Eds) John Wiley and Sons, Chichester, 2001, pp 371-378

3

Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G, Smith MA. Mitochondrial abnormalities in Alzheimer’s disease. Journal of Neuroscience 21(9):3017-3023, 2001

4

Raina AK, Hochman A, Zhu X, Rottkamp CA, Nunomura A, Siedlak SL, Boux H, Castellani RJ, Perry G, Smith MA. Abortive apoptosis in Alzheimer’s disease. Acta Neuropathologica 101(4):305-310, 2001

5

Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA. Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology 60(8):759-767, 2001

6

Zhu X, Castellani RL, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the “two hit” hypothesis. Mechanism of Ageing and Development 123:39-46, 2001

7

Perry G, Nunomura A, Siedla SL, Harris PLR, Zhu X, Castellani RJ, Aliev G, Smith MA. Oxidant and antioxidant responses in Alzheimer disease. Recent Research Developments in Biophysics and Biochemistry 1:35-41, 2001

8

Ishimoto T, Omori N, Mutoh F, Chiba S. Convulsive seizures induced by N-methyl-D-aspartate microinjection into the mesencephalic reticular formation in rats. Epilepsia 42(suppl. 6) ,pp68, 2001

1

千葉　茂. 老年精神医学の近未来. 老年精神医学雑誌. 11:57-59, 2000

2

布村明彦、千葉　茂、Smith MA、Perry G. RNAの酸化とアルツハイマー病. Dementia Japan 14(1):39-45, 2000

3

田端一基、中川朋恵、猪俣光孝、直江寿一郎、石丸雄二、田村義之、武藤福保、千葉　茂: Creutzfeldt-Jakob病の2例に認められたCyclic EEG Changesに類似する脳波所見について−Diazepam静脈内投与による検討−. 日本薬物脳波学会誌 2:56-58, 2000

4

谷内弘道、千葉　茂: 胃全摘術後に出現したビタミンB12欠乏性代謝性脳症の1例. 精神医学 42:851-854, 2000

5

石本隆広、石丸雄二、尾森伸行、田村義之、武藤福保、千葉　茂: 幻覚および錯覚出現時に脳波異常が認められた側頭葉てんかんの1例. てんかんをめぐってXX:45-50, 2000

6

竹林誠治、橋詰清隆、程塚　明、高野勝信、澤村　淳、田中達也、石本隆広、千葉　茂、吉村英敦: 難治性後頭葉てんかんの一手術例. てんかんをめぐってXX:51-58, 2000

7

Ishimoto T, Omori N, Mutoh F, Chiba S. Convulsive seizures induced by N-methyl-D-aspartate microinjection into the mesencephalic reticular formation in rats. Brain Research 881, 152-158, 2000

8

Nunomura A, Chiba S. Avoidance of apoptosis in Alzheimer's disease. Journal of Alzheimer's disease 2(1):59-60, 2000

9

Nunomura A, Perry G, Pappolla MA, Friedland RP, Hirai K, Chiba S, Smith MA. Neuronal oxidative stress precedes amyloid-β deposition in Down's syndrome. Journal of Neuropathology and Experimental Neurology 59(11):1011-1017, 2000

10

Perry G, Nunomura A, Raina AK, Smith MA. Amyloid β junkies. Lancet 355(9205):757, 2000

11

Perry G, Raina AK, Nunomura A, Wataya T, Sayre LM, Smith MA. How important is oxidative damage? Lessons from Alzheimer's disease. Free Radical Biology and Medicine 28(5):831-834, 2000

12

Rottkamp CA, Nunomura A, Hirai K, Sayre LM, Perry G, Smith MA. Will antioxidant fulfill their expectations for the treatment of Alzheimer disease? Mechanisms of Ageing and Development 116(2-3):169-179, 2000

13

Perry G, Nunomura A, Hirai K, Takeda A, Aliev G, Smith MA. Oxidative damage in Alzheimer's disease: the metabolic dimension. International Journal of Developmental Neuroscience 18(4-5):417-421, 2000

14

Perry G, Nunomura A, Smith MA. Amylose dans la maladie d'Alzheimer. In: Les Amyloses, Grateau G, Benson MD, Delpech M (Eds) Medecine-Sciences Flammarion, Paris, 2000, pp 513-523

15

Rottkamp CA, Nunomura A, Raina AK, Sayre LM, Perry G, Smith MA. Oxidative stress, antioxidants and Alzheimer's disease. Alzheimer Disease and Associated Disorders 14(Suppl. 1):S62-66, 2000

16

Cuajungco MP, Goldstein LE, Nunomura A, Smith MA, Lim JT, Atwood CS, Huang X, Farrag YW, Perry G, Bush AI. Evidence that the b-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Ab by zinc. Journal of Biological Chemistry 275(26):19439-19442, 2000

17

Takeda A, Smith MA, Avila J, Nunomura A, Siedlak SL, Zhu X, Perry G, Sayre LM. In Alzheimer disease, heme oxygenase is coincident with Alz50, an epitope of t induced by 4-hydroxy-2-nonenal modification. Journal of Neurochemistry 75(3):1234-1241, 2000

18

Raina AK, Perry G, Nunomura A, Sayre LM, Smith MA. Histochemical and immunocytochemical approaches to the study of oxidative stress. Clinical Chemistry and Laboratory Medicine 38(2):93-97, 2000

19

Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G. Oxidative stress in Alzheimer's disease. Biochimica et Biophysica Acta 1502(1):139-144, 2000

20

Shimohama S, Tanino H, Kawakami N, Okumura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S. Activation of NADPH oxidase in Alzheimer's disease　brains. Biochemical and Biophysical Research Communications 273(1):5-9, 2000

21

Perry G, Kaminski MA, Nunomura A, Raina AK, Smith MA. What oxidative stress tells us about therepeutic targets for Alzheimer's disease. Current Opinion in CPNS Investigational Drugs 2(4):423-426, 2000

22

Smith MA, Nunomura A, Zhu X, Takeda A, Perry G. Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease. Antioxidants & Redox Signaling 2(3):413-420, 2000

23

Perry G, Nunomura A, Friedlich AL, Boswell MV, Brazdil L, Jones PK, Rottkamp CA, Zhu X, Raina AK, Hirai K, Friedland RP, Shi J, Aliev G, Cash A, Russell RL, Wataya T, Shimohama S, Atwood CS, Smith MA. Factors controlling oxidative damage in Alzheimer disease: Metals and mitochondria. In: Yoshikawa T, Toyokuni S, Yamamoto Y, Naito Y(Eds) Free Radicals in Chemistry, Biology and Medicine, OICA International, London, 2000, pp417-423

24

Perry G, Nunomura A, Smith MA. Homeostatic control of oxidant balance in Alzheimer disease. Recent Research Development in Neurochemistry 3:157-159, 2000

25

Perry G. Nunomura A, Jones PK, Rottkamp CA, Zhu X, Aliev G, Cash AD, Smith MA. Oxidative imbalance is a major feature of Alzheimer disease. Current Topics in Biochemical Research 3:151-156, 2000

1

千葉　茂, 吉田幸宏. 抗てんかん薬の作用機序. 臨床精神医学講座　第14巻　精神科薬物療法. 岡崎光邦, 青葉安里編. 350-363, 中山書店, 東京, 1999

2

千葉　茂. てんかん発作の全般化に関わる脳幹の役割についての実験的研究. てんかん治療研究振興財団研究年報, 11:11-16, 1999

3

Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer disease. Journal of Neuroscience 19:1959-1964, 1999

4

Smith MA, Hirai K, Nunomura A, Perry G. Mitochondrial abnormalities: a primary basis for oxidative damage in Alzheimer's disease. Drug Development Research 46:26-33, 1999

5

Raina AK, Takeda A, Nunomura A, Perry G, Smith MA. Genetic evidence for oxidative stress in Alzheimer's disease. NeuroReport 10:1355-1357, 1999

6

Castellani RJ, Smith MA, Nunomura A, Harris PLR, Perry G. Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin? Free Radical Biology & Medicine 26:1508-1512, 1999

7

Gerst JL, Siedlak SL, Nunomura A, Castellani R, Perry G, Smith MA. Role of oxidative stress in frontotemporal dementia. Dementia and Geriatric Cognitive Disorders 10 (Suppl.1) :85-87, 1999

8

Perry G, Roder H, Nunomura A, Takeda A, Friedlich AL, Zhu X, Raina AK, Holbrook N, Siedlak SL, Harris PLR, Smith MA. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. NeuroReport 10:2411-2415, 1999

9

Smith MA, Nunomura A, Takeda A, Perry G. Asking the right questions. Science 285:665, 1999

10

Nunomura A, Perry G, Zhang J, Montine TJ, Takeda A, Chiba S, Smith MA. RNA oxidation in Alzheimer and Parkinson diseases. Journal of Anti-Aging Medicine 2:227-230, 1999

11

Perry G, Hirai K, Nunomura A, Raina A, Smith MA. Neuronal oxidative damage may be brought about by a foundamental shift in redox balance and oxidative metabolism. Recent Research Developments in Neurochemistry 2:277-285, 1999

12

Perry G, Nunomura A, Smith MA. Antioxidant reversal of oxidative stress-induced memory deficits. NeuroReport 10, i, 1999

13

Nunomura A, Perry G, Hirai K, Aliev G, Takeda A, Chiba S, Smith MA. Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome. Annals of the New York Academy of Sciences 893:362- 364, 1999

14

Takei A, Chiba S. Rabdomyolysis associated with pravastatin treatment for major depression. Psychiatry and Clinical Neuroscience 53:539, 1999