研究業績

2017
58. Xin B, Yamamoto M, Fujii K, Ooshio T, Chen X, Okada Y, Watanabe K, Miyokawa N, Furukawa H, Nishikawa Y. Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways. Oncogene advance online publication 8 May 2017; doi: 10.1038/onc.2017.114
57. Nakagawa H, Suzuki N, Hirata Y, Hikiba Y, Hayakawa Y, Kinoshita H, Ihara S, Uchino K, Nishikawa Y, Ijichi H, Otsuka M, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Tateishi K, Koike K. Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands. Proc Natl Acad Sci U S A. 2017 Apr 24. pii: 201619416. doi: 10.1073/pnas.1619416114.[Epub ahead of print] PubMed PMID: 28439013.
56. Tanimizu N, Ichinohe N, Yamamoto M, Akiyama H, Nishikawa Y, Mitaka T. Progressive induction of hepatocyte progenitor cells in chronically injured liver. Sci Rep. 2017 Jan 4;7:39990.
2016
55. Hagiwara M, Matsuno N, Meng LT, Furukori M, Watanabe K, Shonaka T, Imai K, Obara H, Nishikawa Y, Furukawa H. Applicability of Combined Use of Extracorporeal Support and Temperature-Controlled Machine Perfusion Preservation for Liver Procurement of Donors After Cardiac Death in Pigs. Transplant Proc. 2016 May;48(4):1234-8.
54. Furukori M, Matsuno N, Meng LT, Shonaka T, Nishikawa Y, Imai K, Obara H, Furukawa H. Subnormothermic Machine Perfusion Preservation With Rewarming for Donation After Cardiac Death Liver Grafts in Pigs. Transplant Proc. 2016 May;48(4):1239-43.
53. Yamamoto M, Tanaka H, Xin B, Nishikawa Y, Yamazaki K, Shimizu K, Ogawa K. Role of the BrafV637E mutation in hepatocarcinogenesis induced by treatment with diethylnitrosamine in neonatal B6C3F1 mice. 52. Mol Carcinog. 13(7):2283-9, 2016
52. Ikeda Y, Hisano H, Nishikawa Y, Nagasaki Y.Targeting and Treatment of Tumor Hypoxia by Newly Designed Prodrug Possessing High Permeability in Solid Tumors. Mol Pharm. 13(7): 2283-9, 2016
51. Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-Ya K, Mimori K, Suzuki A. Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A. 113(1):E71-80, 2016
2015
50. Chen X, Yamamoto M, Fujii K, Nagahama Y, Ooshio T, Xin B, Okada Y, Furukawa H, Nishikawa Y. Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and noncirrhotic conditions. Cancer Sci. 106(8):972-81, 2015
5. 西川祐司,永濱康晴,肝細胞の細胆管化生と肝内胆管系のリモデリング,胆管膵 70:405-416, 2015
2014
49. Nagahama Y, Sone M, Chen X, Okada Y, Yamamoto M, Xin B, Matsuo Y, Komatsu M, Suzuki A, Enomoto K, Nishikawa Y. Contributions of Hepatocytes and Bile Ductular Cells in Ductular Reactions and Remodeling of the Biliary System after Chronic Liver Injuries. Am J Pathol. 184:3001-12, 2014.

48. Tanimizu N, Nishikawa Y, Ichinohe N, Akiyama H, Mitaka T. Sry HMG box protein 9-positive (Sox9+) epithelial cell adhesion molecule-negative (EpCAM-) biphenotypic cells derived from hepatocytes are involved in mouse liver regeneration. J Biol Chem. 289:7589-98, 2014

47. Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A. 111:1090-5, 2014
2013
46. Nishikawa Y, Sone M, Nagahama Y, Kumagai E, Doi Y, Omori Y, Yoshioka T, Tokairin T, Yoshida M, Yamamoto Y, Ito A, Sugiyama T, Enomoto K. Tumor necrosis factor-α promotes bile ductular transdifferentiation of mature rat hepatocytes in vitro. J Cell Biochem. 114:831-843, 2013
4. 西川祐司,肝細胞と胆管上皮の相互可塑性とその病態生理学的意義,肝胆膵 66:633-643, 2013

3. 榎本克彦,山本洋平,鈴木麻弥,吉岡年明,大森泰文,曽根正行,西川祐司,肝前駆細胞由来胆管上皮と肝外胆管前駆細胞由来胆管上皮の胆道系での接点,肝胆膵 66:613-621, 2013
2012
45. Sone M, Nishikawa Y, Nagahama Y, Kumagai E, Doi Y, Omori Y, Yoshioka T, Tokairin T, Yoshida M, Sugiyama T, Enomoto K. Recovery of mature hepatocytic phenotype following bile ductular transdifferentiation of rat hepatocytes in vitro. Am J Pathol 181:2094-2104, 2012

44. Nishikawa Y. Transdifferentiation of mature hepatocytes into bile ductular cells within a collagen gel matrix. Methods in Mol Biol 826:153-60, 2012
2.西川祐司,永濵康晴,曽根正行,山本雅大,榎本克彦.肝細胞と胆管上皮の相互可塑性.生化学 84:649-657, 2012
2011
43. Inagaki M, Furukawa H, Satake Y, Okada Y, Chiba S, Nishikawa Y, Ogawa K. Replacement of liver parenchyma in analbuminemic rats with allogenic hepatocytes is facilitated by intrabone marrow transplantation. Cell Transplant 20:1479-1489, 2011

42. Yamamoto H, Yamamoto F, Tanaka F, Nishikawa, Y. Vulnerability of an equine pericardial roll graft to Gram-positive cocci after graft replacement for a ruptured infected abdominal aorta. Interact Cardiovasc Thorac Surg 12:866-868, 2011

41. Kawasaki Y, Omori Y, Li Q, Nishikawa Y, Yoshioka T, Yoshida M, Ishikawa K, Enomoto K. Cytoplasmic accumulation of connexin32 expands cancer stem cell population in human HuH7 hepatoma cells by enhancing its self-renewal. Int J Cancer 128:51-62, 2011
1. 西川祐司,実験病理学の楽しみ第8回 肝臓病理学-細胆管反応をめぐって-,病理と臨床 29:1263-1269, 2011
2010
40. Yoshioka T, Nishikawa Y, Ito R, Kawamata M, Doi Y, YamamotoY, Yoshida M, Omori Y, Kotanagi H, Masuko T, Enomoto K. Significance of integrin αvβ5 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte-derived heregulin. Cancer Sci 101:2011-2018, 2010
2009
39. Yoshida M, Nishikawa Y, Yamamoto Y, Doi Y, Tokairin T, Yoshioka T, Omori Y, Watanabe A, Takahashi N, Yoshioka T, Miura I, Sawada K, Enomoto K. Mast cell leukemia with rapidly progressing portal hypertension. Pathol Int 59:817-822, 2009

38. Nishikawa Y, Ohi N, Yagisawa A, Doi Y, Yamamoto Y, Yoshida M, Tokairin T, Yoshioka T, Omori Y, Enomoto K. Suppressive effect of orthovanadate on hepatic stellate cell activation and liver fibrosis in rats. Am J Pathol 174:881-890, 2009
2008
37. Sasaki Y, Kamata S, Saito K, Nishikawa Y, Ogawa J. Pseudoangiomatous stromal hyperplasia (PASH) of the mammary gland: report of a case. Surg Today38:340-343, 2008

36. Tokairin T, Nishikawa Y, Watanabe H, Doi Y, Omori Y, Yoshioka T, Yamamoto Y, Yoshida M, Nishimura T, Li Q, Arai H, Ishida A, Takada G, Enomoto K. Osteopontin expression in the liver with severe perisinusoidal fibrosis: Autopsy case of Down syndrome with transient myeloproliferative disorder. Pathol Int 58:64-68, 2008
2007
35. Miyakoshi N, Nishikawa Y, Shimada Y, Okada K, Yoshida M, Enomoto K, Itoi E. Intraosseous malignant peripheral nerve sheath tumor with focal epithelioid differentiation of the thoracic spine. Neurol India 55:64-66, 2007

34. Ito A*, Nishikawa Y*, Ohnuma K, Ohnuma I, Koma Y, Sato A, Enomoto K, Tsujimura T, Yokozaki H. SgIGSF is a novel biliary-epithelial cell adhesion molecule mediating duct/ductule development. Hepatology 45:684-694, 2007 (*equally contributed)

33. Li Q, Omori Y, Nishikawa Y, Yoshioka T, Yamamoto Y, Enomoto K. Cytoplasmic accumulation of connexin32 protein enhances motility and metastatic ability of human hepatoma cells in vitro and in vivo. Int J Cancer 121:536-46, 2007

32. Omori Y, Li Q, Nishikawa Y, Yoshioka T, Yoshida M, Nishimura T, Enomoto K. Pathological significance of intracytoplasmic connexin proteins: implication in tumor progression.J Membr Biol 218:73-77, 2007

31. Yoshida M, Nishikawa Y, Omori Y, Yoshioka T, Tokairin T, McCourt P, Enomoto K. Involvement of signaling of VEGF and TGF-beta in differentiation of sinusoidal endothelial cells during culture of fetal rat liver cells. Cell Tissue Res 329:273-82, 2007
2006
30. Ishii H, Takahashi T, Toyono M, Tamura M, Harada K, Yoshida M, Nishikawa Y, Enomoto K, Takada G. Acid sphingomyelinase deficiency: cardiac dysfunction and characteristic findings of the coronary arteries. J Inherit Metab Dis 9:232-234, 2006

29. Ohi N, Nishikawa Y, Tokairin T, Yamamoto Y, Doi Y, Omori Y, Enomoto K. Maintenance of Bad phosphorylation prevents apoptosis of rat hepatic sinusoidal endothelial cells in vitro and in vivo. Am J Pathol 168:1097-1106, 2006
~2005
28. Nishikawa Y, Doi Y, Watanabe H, Tokairin T, Omori Y, Su M, Yoshioka T, Enomoto K. Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro. Am J Pathol166:1077-1088, 2005

27. Enomoto K, Nishikawa Y, Omori Y, Tokairin T, Yoshida M, Ohi N, Nishimura T, Yamamoto Y, Li Q. Cell biology and pathology of liver sinusoidal endothelial cells. Med Electr Microscop37:208-15, 2004

26. Yamamoto Y, Nishikawa Y, Tokairin T, Omori Y, Enomoto K. Increased expression of H19 non-coding mRNA follows hepatocyte proliferation in the rat and mouse. J Hepatol40:808-14, 2004

25. Ishizaki Y, Omori Y, Momiyama M, Nishikawa Y, Tokairin T, Manabe M, Enomoto K. Reduced expression and aberrant localization of p120catenin in human squamous cell carcinoma of the skin. J Dermatol Sci 34:99-108, 2004

24. Momiyama M, Omori Y, Ishizaki Y, Nishikawa Y, Tokairin T, Ogawa J, Enomoto K. Connexin26-mediated gap junctional communication reverses the malignant phenotype of MCF-7 breast cancer cells. Cancer Sci94:501-7, 2003

23. Higuchi N, Maruyama H, Kuroda T, Kameda S, Iino N, Kawachi H, Nishikawa Y, Hanawa H, Tahara H, Miyazaki J, Gejyo F. Hydrodynamics-based delivery of the viral interleukin-10 gene suppresses experimental crescentic glomerulonephritis in Wistar-Kyoto rats. Gene Ther10:1297-310, 2003

22. Kameda S, Maruyama H, Higuchi N, Nakamura G, Iino N, Nishikawa Y, Miyazaki J, Gejyo F. Hydrodynamics-based transfer of PCR-amplified DNA fragments into rat liver. Biochem Biophys Res Commun 309:929-36, 2003

21. Tokairin T, Nishikawa Y, Doi Y, Watanabe H, Omori Y, Su M, Yoshioka T, Enomoto K. A highly selective isolation of rat sinusoidal endothelial cells by immunomagnetic beads using SE-1 monoclonal antibody. J Hepatol 36:725-733, 2002

20. Su M, Tokairin T, Nishikawa Y, Yoshioka T, Takahashi O, Watanabe H, Doi Y, Omori Y, Yoshioka T, Sageshima M, Tanaka T, Enomoto K. Primary osteosarcoma of the uterine corpus: case report and review of the literature. Pathol Int 52:158-63, 2002

19. Maruyama H, Higuchi N, Nishikawa Y, Kameda S, Iino N, Kazama JJ, Takahashi N, Sugawa M, Hanawa H, Tada N, Miyazaki J, Geiyo F. High-level expression of naked DNA delivered to rat liver via tail vein injection. J Gene Med 4:333-341, 2002

18. Maruyama H, Higuchi N, Nishikawa Y, Hirahara H, Iino N, Kameda S, Kawachi H, Yoita E, Gejyo F, Miyazaki J. Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats. Hum Gene Ther 13:455-468, 2002

17. Wang Z, Nishikawa Y, Wang M, Carr BI. Induction of apoptosis via mitogen-activated protein kinase pathway by a K vitamin analog in rat hepatocytes. J Hepatol. 36:85-92, 2002

16. Muto O, Sato Y, Umeki Y, Yoshida K, Yoshioka T, Nishikawa Y, Nakamura T, Mori M, Koyama K, Enomoto K. HGF/SF-induced spreading of MDCK cells correlates with disappearance of barmotin/7H6, a tight junction-associated protein, from the cell membrane. Cell Biol Int 24:439-446, 2000

15. Nishikawa Y, Wang Z, Kerns J, Wilcox CS, Carr BI. Inhibition of hepatoma cell growth in vitro by arylating and non-arylating K vitamin analogs. Significance of protein tyrosine phosphatase inhibition. J Biol Chem 274:34803-34810, 1999

14. Nishikawa Y, Wang M, Carr BI. Changes in transforming growth factor-beta (TGF-beta) receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors assocated with increased sensitivity to TGF-beta-mediated growth inhibition. J Cell Physiol 176:612-623, 1998

13. Ni R, Nishikawa Y, Carr BI. Cell growth inhibition by a novel vitamin K is associated with induction of protein tyrosine phosphorylation. J Biol Chem 237:9906-9911, 1998

12. Nishikawa Y, Kar S, Wiest L, Pegg AE, Carr BI. Inhibition of spermidine synthase gene expression by transforming growth factor-beta (TGF-beta). Biochem J 321:537-543, 1997

11. Nishikawa Y, Tokusashi Y, Kadohama T, Nishimori H, Ogawa K. Hepatocytic cells form bile duct-like structures within a three-dimensional collagen gel matrix. Exp Cell Res 223:357-371, 1996

10. Bouzahzah B, Nishikawa Y, Simon D, Carr BI. Growth control and gene expression in a new hepatocellular carcinoma cell line, Hep40: inhibitory actions of vitamin K. J Cell Physiol 165:459-467, 1995

09. Tokusashi Y, Nishikawa Y, Ogawa K. Differentiation of the normal mutant rat albumin genes on hepatic tissue sections by in situ PCR. Nucleic Acids Res 23:3790-3791, 1995

08. Nishikawa Y, Carr BI, Wang M, Kar S, Finn F, Dowd P, Zheng ZB, Kerns J, Naganathan S. Growth inhibition of hepatoma cells by vitamin K and its analogs. J Biol Chem 270:28304-28310, 1995

07. Nishikawa Y, Tokusashi Y, Saito Y, Ogawa K, Miyokawa N, Katagiri M. A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. Am J Surg Pathol 18:832-836, 1994

06. Nishikawa Y, Ohta T, Ogawa K, Nagase S. Reversion of altered phenotype of cultured rat hepatocytes after intrahepatic and intrasplenic transplantation. Lab Invest 70:925-932, 1994

05. Nishikawa Y, Takahashi T, Ogawa K. Redistribution of glutamate and GABA in the cerebral neocortex and hipocampus of Mongolian gerbil after transient ischemia. Mol Chem Neuropathol 22:25-41, 1994

04. Nishikawa Y, Sakai H, Inagaki M, Fukuda I, Ogawa K. Genotypic differentiation of the intrahepatically transplanted hyperplastic nodule cells of analbuminemic and normal rat origin by polymerase chain reaction. Jpn J Cancer Res 81:711-714, 1990

03. Nishikawa Y, Takahashi T, Shimoda A. Morphological studies on cerebral cortical lesions induced by transient ischemia in Mongolian gerbil - diffuse and peripheral pallor of the neuronal perikarya. Acta Neuropathol 78:1-8, 1989

02. Azuma M, Sazaki K, Nishikawa Y, Takahashi T, Shimoda A, Suzutani T, Yoshida I, Sakuma T, Nakaya K. Correlation between augmented resistance to influenza virus infection and histological changes in lung of mice treated with trehalose-6,6'-dimycolate. J Biol Response Mod7:437-482, 1988

01. Muraoka S, Takahashi T, Ando M, Nishikawa Y, Fujita M, Shimoda A. Minute carcinoid tumor of the uterine cervix associated with microinvasive adenocarcinoma, with reference to its histogenesis. Acta Pathol. Jpn.37:1183-1198, 1987