- 2017
- 58. Xin B, Yamamoto M, Fujii K, Ooshio T, Chen X, Okada Y, Watanabe K,
Miyokawa N, Furukawa H, Nishikawa Y. Critical role of Myc activation in
mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways.
Oncogene advance online publication 8 May 2017; doi: 10.1038/onc.2017.114
- 57. Nakagawa H, Suzuki N, Hirata Y, Hikiba Y, Hayakawa Y, Kinoshita H,
Ihara S, Uchino K, Nishikawa Y, Ijichi H, Otsuka M, Arita J, Sakamoto Y,
Hasegawa K, Kokudo N, Tateishi K, Koike K. Biliary epithelial injury-induced
regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary
glands. Proc Natl Acad Sci U S A. 2017 Apr 24. pii: 201619416. doi: 10.1073/pnas.1619416114.[Epub
ahead of print] PubMed PMID: 28439013.
- 56. Tanimizu N, Ichinohe N, Yamamoto M, Akiyama H, Nishikawa Y, Mitaka
T. Progressive induction of hepatocyte progenitor cells in chronically
injured liver. Sci Rep. 2017 Jan 4;7:39990.
- 2016
- 55. Hagiwara M, Matsuno N, Meng LT, Furukori M, Watanabe K, Shonaka T,
Imai K, Obara H, Nishikawa Y, Furukawa H. Applicability of Combined Use
of Extracorporeal Support and Temperature-Controlled Machine Perfusion
Preservation for Liver Procurement of Donors After Cardiac Death in Pigs.
Transplant Proc. 2016 May;48(4):1234-8.
- 54. Furukori M, Matsuno N, Meng LT, Shonaka T, Nishikawa Y, Imai K, Obara
H, Furukawa H. Subnormothermic Machine Perfusion Preservation With Rewarming
for Donation After Cardiac Death Liver Grafts in Pigs. Transplant Proc.
2016 May;48(4):1239-43.
- 53. Yamamoto M, Tanaka H, Xin B, Nishikawa Y, Yamazaki K, Shimizu K, Ogawa
K. Role of the BrafV637E mutation in hepatocarcinogenesis induced by treatment
with diethylnitrosamine in neonatal B6C3F1 mice. 52. Mol Carcinog. 13(7):2283-9,
2016
- 52. Ikeda Y, Hisano H, Nishikawa Y, Nagasaki Y.Targeting and Treatment
of Tumor Hypoxia by Newly Designed Prodrug Possessing High Permeability
in Solid Tumors. Mol Pharm. 13(7): 2283-9, 2016
- 51. Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano
Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki
T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-Ya K, Mimori
K, Suzuki A. Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis
in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A. 113(1):E71-80, 2016
- 2015
- 50. Chen X, Yamamoto M, Fujii K, Nagahama Y, Ooshio T, Xin B, Okada Y,
Furukawa H, Nishikawa Y. Differential reactivation of fetal/neonatal genes
in mouse liver tumors induced in cirrhotic and noncirrhotic conditions.
Cancer Sci. 106(8):972-81, 2015
- 5. 西川祐司,永濱康晴,肝細胞の細胆管化生と肝内胆管系のリモデリング,胆管膵 70:405-416, 2015
- 2014
- 49. Nagahama Y, Sone M, Chen X, Okada Y, Yamamoto M, Xin B, Matsuo Y, Komatsu
M, Suzuki A, Enomoto K, Nishikawa Y. Contributions of Hepatocytes and Bile
Ductular Cells in Ductular Reactions and Remodeling of the Biliary System
after Chronic Liver Injuries. Am J Pathol. 184:3001-12, 2014.
48. Tanimizu N, Nishikawa Y, Ichinohe N, Akiyama H, Mitaka T. Sry HMG box
protein 9-positive (Sox9+) epithelial cell adhesion molecule-negative (EpCAM-)
biphenotypic cells derived from hepatocytes are involved in mouse liver
regeneration. J Biol Chem. 289:7589-98, 2014
47. Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa
Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano
K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M,
Maeda S. Loss of liver E-cadherin induces sclerosing cholangitis and promotes
carcinogenesis. Proc Natl Acad Sci U S A. 111:1090-5, 2014
- 2013
- 46. Nishikawa Y, Sone M, Nagahama Y, Kumagai E, Doi Y, Omori Y, Yoshioka
T, Tokairin T, Yoshida M, Yamamoto Y, Ito A, Sugiyama T, Enomoto K. Tumor
necrosis factor-α promotes bile ductular transdifferentiation of mature
rat hepatocytes in vitro. J Cell Biochem. 114:831-843, 2013
- 4. 西川祐司,肝細胞と胆管上皮の相互可塑性とその病態生理学的意義,肝胆膵 66:633-643, 2013
3. 榎本克彦,山本洋平,鈴木麻弥,吉岡年明,大森泰文,曽根正行,西川祐司,肝前駆細胞由来胆管上皮と肝外胆管前駆細胞由来胆管上皮の胆道系での接点,肝胆膵
66:613-621, 2013
- 2012
- 45. Sone M, Nishikawa Y, Nagahama Y, Kumagai E, Doi Y, Omori Y, Yoshioka
T, Tokairin T, Yoshida M, Sugiyama T, Enomoto K. Recovery of mature hepatocytic
phenotype following bile ductular transdifferentiation of rat hepatocytes
in vitro. Am J Pathol 181:2094-2104, 2012
44. Nishikawa Y. Transdifferentiation of mature hepatocytes into bile ductular
cells within a collagen gel matrix. Methods in Mol Biol 826:153-60, 2012
- 2.西川祐司,永濵康晴,曽根正行,山本雅大,榎本克彦.肝細胞と胆管上皮の相互可塑性.生化学 84:649-657, 2012
- 2011
- 43. Inagaki M, Furukawa H, Satake Y, Okada Y, Chiba S, Nishikawa Y, Ogawa
K. Replacement of liver parenchyma in analbuminemic rats with allogenic
hepatocytes is facilitated by intrabone marrow transplantation. Cell Transplant
20:1479-1489, 2011
42. Yamamoto H, Yamamoto F, Tanaka F, Nishikawa, Y. Vulnerability of an
equine pericardial roll graft to Gram-positive cocci after graft replacement
for a ruptured infected abdominal aorta. Interact Cardiovasc Thorac Surg
12:866-868, 2011
41. Kawasaki Y, Omori Y, Li Q, Nishikawa Y, Yoshioka T, Yoshida M, Ishikawa
K, Enomoto K. Cytoplasmic accumulation of connexin32 expands cancer stem
cell population in human HuH7 hepatoma cells by enhancing its self-renewal.
Int J Cancer 128:51-62, 2011
- 1. 西川祐司,実験病理学の楽しみ第8回 肝臓病理学-細胆管反応をめぐって-,病理と臨床 29:1263-1269, 2011
- 2010
- 40. Yoshioka T, Nishikawa Y, Ito R, Kawamata M, Doi Y, YamamotoY, Yoshida
M, Omori Y, Kotanagi H, Masuko T, Enomoto K. Significance of integrin αvβ5
and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas
stimulated by hepatocyte-derived heregulin. Cancer Sci 101:2011-2018, 2010
- 2009
- 39. Yoshida M, Nishikawa Y, Yamamoto Y, Doi Y, Tokairin T, Yoshioka T,
Omori Y, Watanabe A, Takahashi N, Yoshioka T, Miura I, Sawada K, Enomoto
K. Mast cell leukemia with rapidly progressing portal hypertension. Pathol
Int 59:817-822, 2009
38. Nishikawa Y, Ohi N, Yagisawa A, Doi Y, Yamamoto Y, Yoshida M, Tokairin
T, Yoshioka T, Omori Y, Enomoto K. Suppressive effect of orthovanadate
on hepatic stellate cell activation and liver fibrosis in rats. Am J Pathol
174:881-890, 2009
- 2008
- 37. Sasaki Y, Kamata S, Saito K, Nishikawa Y, Ogawa J. Pseudoangiomatous
stromal hyperplasia (PASH) of the mammary gland: report of a case. Surg
Today38:340-343, 2008
36. Tokairin T, Nishikawa Y, Watanabe H, Doi Y, Omori Y, Yoshioka T, Yamamoto
Y, Yoshida M, Nishimura T, Li Q, Arai H, Ishida A, Takada G, Enomoto K.
Osteopontin expression in the liver with severe perisinusoidal fibrosis:
Autopsy case of Down syndrome with transient myeloproliferative disorder.
Pathol Int 58:64-68, 2008
- 2007
- 35. Miyakoshi N, Nishikawa Y, Shimada Y, Okada K, Yoshida M, Enomoto K,
Itoi E. Intraosseous malignant peripheral nerve sheath tumor with focal
epithelioid differentiation of the thoracic spine. Neurol India 55:64-66,
2007
34. Ito A*, Nishikawa Y*, Ohnuma K, Ohnuma I, Koma Y, Sato A, Enomoto K,
Tsujimura T, Yokozaki H. SgIGSF is a novel biliary-epithelial cell adhesion
molecule mediating duct/ductule development. Hepatology 45:684-694, 2007
(*equally contributed)
33. Li Q, Omori Y, Nishikawa Y, Yoshioka T, Yamamoto Y, Enomoto K. Cytoplasmic
accumulation of connexin32 protein enhances motility and metastatic ability
of human hepatoma cells in vitro and in vivo. Int J Cancer 121:536-46,
2007
32. Omori Y, Li Q, Nishikawa Y, Yoshioka T, Yoshida M, Nishimura T, Enomoto
K. Pathological significance of intracytoplasmic connexin proteins: implication
in tumor progression.J Membr Biol 218:73-77, 2007
31. Yoshida M, Nishikawa Y, Omori Y, Yoshioka T, Tokairin T, McCourt P,
Enomoto K. Involvement of signaling of VEGF and TGF-beta in differentiation
of sinusoidal endothelial cells during culture of fetal rat liver cells.
Cell Tissue Res 329:273-82, 2007
- 2006
- 30. Ishii H, Takahashi T, Toyono M, Tamura M, Harada K, Yoshida M, Nishikawa
Y, Enomoto K, Takada G. Acid sphingomyelinase deficiency: cardiac dysfunction
and characteristic findings of the coronary arteries. J Inherit Metab Dis
9:232-234, 2006
29. Ohi N, Nishikawa Y, Tokairin T, Yamamoto Y, Doi Y, Omori Y, Enomoto
K. Maintenance of Bad phosphorylation prevents apoptosis of rat hepatic
sinusoidal endothelial cells in vitro and in vivo. Am J Pathol 168:1097-1106,
2006
- ~2005
- 28. Nishikawa Y, Doi Y, Watanabe H, Tokairin T, Omori Y, Su M, Yoshioka
T, Enomoto K. Transdifferentiation of mature rat hepatocytes into bile
duct-like cells in vitro. Am J Pathol166:1077-1088, 2005
27. Enomoto K, Nishikawa Y, Omori Y, Tokairin T, Yoshida M, Ohi N, Nishimura
T, Yamamoto Y, Li Q. Cell biology and pathology of liver sinusoidal endothelial
cells. Med Electr Microscop37:208-15, 2004
26. Yamamoto Y, Nishikawa Y, Tokairin T, Omori Y, Enomoto K. Increased
expression of H19 non-coding mRNA follows hepatocyte proliferation in the
rat and mouse. J Hepatol40:808-14, 2004
25. Ishizaki Y, Omori Y, Momiyama M, Nishikawa Y, Tokairin T, Manabe M,
Enomoto K. Reduced expression and aberrant localization of p120catenin
in human squamous cell carcinoma of the skin. J Dermatol Sci 34:99-108,
2004
24. Momiyama M, Omori Y, Ishizaki Y, Nishikawa Y, Tokairin T, Ogawa J,
Enomoto K. Connexin26-mediated gap junctional communication reverses the
malignant phenotype of MCF-7 breast cancer cells. Cancer Sci94:501-7, 2003
23. Higuchi N, Maruyama H, Kuroda T, Kameda S, Iino N, Kawachi H, Nishikawa
Y, Hanawa H, Tahara H, Miyazaki J, Gejyo F. Hydrodynamics-based delivery
of the viral interleukin-10 gene suppresses experimental crescentic glomerulonephritis
in Wistar-Kyoto rats. Gene Ther10:1297-310, 2003
22. Kameda S, Maruyama H, Higuchi N, Nakamura G, Iino N, Nishikawa Y, Miyazaki
J, Gejyo F. Hydrodynamics-based transfer of PCR-amplified DNA fragments
into rat liver. Biochem Biophys Res Commun 309:929-36, 2003
21. Tokairin T, Nishikawa Y, Doi Y, Watanabe H, Omori Y, Su M, Yoshioka
T, Enomoto K. A highly selective isolation of rat sinusoidal endothelial
cells by immunomagnetic beads using SE-1 monoclonal antibody. J Hepatol
36:725-733, 2002
20. Su M, Tokairin T, Nishikawa Y, Yoshioka T, Takahashi O, Watanabe H,
Doi Y, Omori Y, Yoshioka T, Sageshima M, Tanaka T, Enomoto K. Primary osteosarcoma
of the uterine corpus: case report and review of the literature. Pathol
Int 52:158-63, 2002
19. Maruyama H, Higuchi N, Nishikawa Y, Kameda S, Iino N, Kazama JJ, Takahashi
N, Sugawa M, Hanawa H, Tada N, Miyazaki J, Geiyo F. High-level expression
of naked DNA delivered to rat liver via tail vein injection. J Gene Med
4:333-341, 2002
18. Maruyama H, Higuchi N, Nishikawa Y, Hirahara H, Iino N, Kameda S, Kawachi
H, Yoita E, Gejyo F, Miyazaki J. Kidney-targeted naked DNA transfer by
retrograde renal vein injection in rats. Hum Gene Ther 13:455-468, 2002
17. Wang Z, Nishikawa Y, Wang M, Carr BI. Induction of apoptosis via mitogen-activated
protein kinase pathway by a K vitamin analog in rat hepatocytes. J Hepatol.
36:85-92, 2002
16. Muto O, Sato Y, Umeki Y, Yoshida K, Yoshioka T, Nishikawa Y, Nakamura
T, Mori M, Koyama K, Enomoto K. HGF/SF-induced spreading of MDCK cells
correlates with disappearance of barmotin/7H6, a tight junction-associated
protein, from the cell membrane. Cell Biol Int 24:439-446, 2000
15. Nishikawa Y, Wang Z, Kerns J, Wilcox CS, Carr BI. Inhibition of hepatoma
cell growth in vitro by arylating and non-arylating K vitamin analogs.
Significance of protein tyrosine phosphatase inhibition. J Biol Chem 274:34803-34810,
1999
14. Nishikawa Y, Wang M, Carr BI. Changes in transforming growth factor-beta
(TGF-beta) receptors of rat hepatocytes during primary culture and liver
regeneration: increased expression of TGF-beta receptors assocated with
increased sensitivity to TGF-beta-mediated growth inhibition. J Cell Physiol
176:612-623, 1998
13. Ni R, Nishikawa Y, Carr BI. Cell growth inhibition by a novel vitamin
K is associated with induction of protein tyrosine phosphorylation. J Biol
Chem 237:9906-9911, 1998
12. Nishikawa Y, Kar S, Wiest L, Pegg AE, Carr BI. Inhibition of spermidine
synthase gene expression by transforming growth factor-beta (TGF-beta).
Biochem J 321:537-543, 1997
11. Nishikawa Y, Tokusashi Y, Kadohama T, Nishimori H, Ogawa K. Hepatocytic
cells form bile duct-like structures within a three-dimensional collagen
gel matrix. Exp Cell Res 223:357-371, 1996
10. Bouzahzah B, Nishikawa Y, Simon D, Carr BI. Growth control and gene
expression in a new hepatocellular carcinoma cell line, Hep40: inhibitory
actions of vitamin K. J Cell Physiol 165:459-467, 1995
09. Tokusashi Y, Nishikawa Y, Ogawa K. Differentiation of the normal mutant
rat albumin genes on hepatic tissue sections by in situ PCR. Nucleic Acids
Res 23:3790-3791, 1995
08. Nishikawa Y, Carr BI, Wang M, Kar S, Finn F, Dowd P, Zheng ZB, Kerns
J, Naganathan S. Growth inhibition of hepatoma cells by vitamin K and its
analogs. J Biol Chem 270:28304-28310, 1995
07. Nishikawa Y, Tokusashi Y, Saito Y, Ogawa K, Miyokawa N, Katagiri M.
A case of apocrine adenocarcinoma associated with hamartomatous apocrine
gland hyperplasia of both axillae. Am J Surg Pathol 18:832-836, 1994
06. Nishikawa Y, Ohta T, Ogawa K, Nagase S. Reversion of altered phenotype
of cultured rat hepatocytes after intrahepatic and intrasplenic transplantation.
Lab Invest 70:925-932, 1994
05. Nishikawa Y, Takahashi T, Ogawa K. Redistribution of glutamate and
GABA in the cerebral neocortex and hipocampus of Mongolian gerbil after
transient ischemia. Mol Chem Neuropathol 22:25-41, 1994
04. Nishikawa Y, Sakai H, Inagaki M, Fukuda I, Ogawa K. Genotypic differentiation
of the intrahepatically transplanted hyperplastic nodule cells of analbuminemic
and normal rat origin by polymerase chain reaction. Jpn J Cancer Res 81:711-714,
1990
03. Nishikawa Y, Takahashi T, Shimoda A. Morphological studies on cerebral
cortical lesions induced by transient ischemia in Mongolian gerbil - diffuse
and peripheral pallor of the neuronal perikarya. Acta Neuropathol 78:1-8,
1989
02. Azuma M, Sazaki K, Nishikawa Y, Takahashi T, Shimoda A, Suzutani T,
Yoshida I, Sakuma T, Nakaya K. Correlation between augmented resistance
to influenza virus infection and histological changes in lung of mice treated
with trehalose-6,6'-dimycolate. J Biol Response Mod7:437-482, 1988
01. Muraoka S, Takahashi T, Ando M, Nishikawa Y, Fujita M, Shimoda A. Minute
carcinoid tumor of the uterine cervix associated with microinvasive adenocarcinoma,
with reference to its histogenesis. Acta Pathol. Jpn.37:1183-1198, 1987